SGER: Accumulation of Particulates in Complex Flows: Characterization by NMR Imaging

abstractcts - 0425187 n。这项研究的任务是探测与工业和生物系统相关的复杂流动中分散颗粒（颗粒或液滴）的行为。浓缩分散体（含有许多离散颗粒或液滴的液体）的流动在制药、食品、石油和塑料工业的许多过程中都有发现，但它们的行为很难控制，通常是由于不断相互作用的颗粒或液滴分布不均匀。本研究的智力价值来自于量化复杂流动几何形状和随时间变化的流动中颗粒分布的目标。在复杂的流动中（同时存在剪切和延伸），现有的集中悬浮液连续体模型通常不能预测观察到的颗粒分布，复杂几何形状的数值模拟由于密集的计算而负担过重而不实用，并且实验数据稀疏。然后，我们的目标是在简化的模型系统中获取浓缩悬浮液和乳剂的精确测量集，这些系统可以捕获真实循环，生物反应器或制造过程的关键元素。我们将应用非侵入性核磁共振成像（NMRI）以及光学方法来量化这些系统中的浓度和速度分布，并将观测结果与颗粒特性联系起来。NMRI在体外和体内不透明系统中应用的巨大能力为光学技术无法达到的系统开辟了一个全新的维度。本研究将解决的复杂流动的目标元素是扰动流动中的颗粒积聚。我们的目标是确定最重要的系统参数决定颗粒积累，并量化颗粒浓度和速度曲线作为测试连续体模型预测的基准。该研究有望揭示对色散动力学行为的新见解。这项研究计划的广泛影响主要有两个方向。首先，我们的基础研究成果可以作为长期的实用指南来实施，从药物递送微球的流体动力学靶向到塑料和药物加工。此外，我们实验室的研究生和本科生将体验到密集的研究训练的教育价值。

AbstractCTS-0425187N. Shapley, Columbia University Accumulation of Particulates in Complex Flows: Characterization by NMR Imaging The mission of this research is to probe the behavior of dispersed particulates (particles or droplets) in complex flows that are relevant to industrial and biological systems. Flows of concentrated dispersions (liquids containing many discrete particles or droplets) are found in many processes in the pharmaceutical, food, oil, and plastics industries, but their behavior is difficult to control, generally due to nonuniform distributions of the continually interacting particles or droplets. The intellectual merit of this research derives from the goal of quantifying the distribution of particulates in complex flow geometries and time-dependent flows. In complex flows (where both shearing and elongation are present), existing continuum models of concentrated suspensions often do not predict observed particle distributions, numerical simulations in complex geometries are too overburdened by intensive computations to be practical, and experimental data are sparse. Our aim then is to acquire incisive sets of measurements of concentrated suspensions and emulsions in simplified model systems that capture key elements of real circulatory, bioreactor, or manufacturing processes. We will apply noninvasive nuclear magnetic resonance imaging (NMRI) along with optical methods to quantify concentration and velocity distributions in these systems and relate observations to particulate properties. The enormous capability of NMRI to be employed in opaque systems and both in vitro and in vivo opens up an entire new dimension of systems that are not accessible to optical techniques. The targeted element of complex flows that this study will address is particulate accumulation in disturbed flows. We aim to identify the most important system parameters determining particulate accumulation and to quantify particulate concentration and velocity profiles as benchmarks for testing continuum model predictions. The study is anticipated to reveal new insights into the behavior of dispersion dynamics. The broader impact of this research program has two main directions. First, there are the applications in which our fundamental research results can be implemented as practical guidelines in the long term, ranging from hydrodynamic targeting of drug delivery microspheres to plastics and pharmaceuticals processing. In addition, there is the educational value of the intensive research training that the graduate and undergraduates dents in our laboratory will experience.