Purchase of a High Resolution ESI-TOF Mass Spectrometer

在化学研究仪器和设施：系级多用户仪器(CRIF：MU)计划的支持下，南佛罗里达大学化学系将购买一台具有高性能液相色谱仪(HPLC)的高分辨率电喷雾飞行时间(ESI-TOF)质谱仪。该质谱仪将加强各种研究项目，包括：(A)海洋天然产物的分离和表征；(B)有机合成方法的开发及其在合成具有重要生物意义的天然产物中的应用；(C)限制二肽单元作为β-发夹稳定剂的表征；(D)新型酰胺代谢物的生物合成；(E)新型N-硫代β-内酰胺类化合物的设计和合成；以及(F)新型纳米级自组装笼子的研究。该仪器将被纳入高级“方法”课程和研究生级别的“研究工具”课程。高分辨率质谱仪还将促进美国联邦其他部门与该地区行业和大学之间的合作。质谱学(MS)是一种用于探测密切结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。它是发展最快、使用最广泛的分析仪器技术之一。该仪器将影响海洋天然产物、多肽化学、合成有机化学和无机化学、生物化学、材料化学和纳米技术等领域的研究。

With support from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation (CRIF:MU) Program, the Department of Chemistry at the University of South Florida will acquire a high-resolution electrospray time-of-flight (ESI-TOF) mass spectrometer with a high performance liquid chromatogram (HPLC). This mass spectrometer will enhance a variety of research projects including: (a) the isolation and characterization of marine natural products; (b) the development of organic synthetic methodologies and their application to the synthesis of biologically important natural products; (c) characterization of constrained dipeptide units as beta-hairpin stabilizers; (d) the biosynthesis of novel amide metabolites; (e) the design and synthesis of novel N-thiolated beta-lactams; and (f) the study of novel, nano-scale, self-assembled cages. The instrument will be incorporated into both a senior-level "Methods" course and a graduate-level "Tools of Research" course. The high-resolution mass spectrometer will also facilitate collaboration between other USF departments and area industries and universities.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It is one of the fastest growing and most widely used analytical instrumentation techniques. The instrument will impact research in the areas of marine natural products, peptide chemistry, synthetic organic and inorganic chemistry, biochemistry, materials chemistry, and nanotechnology.