CAREER: Roles of Transition Metals in Dioxygen Activation and Superoxide Scavenging

这个CAREER奖在无机、生物无机和有机金属化学项目中支持约翰霍普金斯大学贾斯汀罗斯教授通过测定氧同位素效应来探测O2与过渡金属的相互作用。测量自然丰度中O-16和O-18比值的变化将揭示在二氧与过渡金属试剂相互作用中起作用的热力学和动力学因素。氧化还原过程中氧结合的变化在工业氧化和O2作为能源的生物利用中是重要的。金属- o2加合物的性质将被研究，电化学数据将被收集，以解决这些物种进行C-H和O-H氧化的能力。探讨了电子、质子和氢原子转移反应的驱动力与速率之间的关系。巴尔的摩市的一项针对中学女生的强化指导计划将建立在与马里兰科学中心相关的夏季讲习班的基础上。在两年的研讨会以演示为中心之后，第三年将重点放在为科学中心制作生物技术展示上。氧化过程在生物系统和工业环境中是重要的。单质双氧与过渡金属配合物相互作用的机理与大规模化学和生物化学有关。比较氧同位素的动力学和平衡分布将有助于深入了解伴随氧进入金属配合物和有机底物的活化和结合而发生的键合变化。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Justine Roth at Johns Hopkins University to probe the interaction of O2 with transition metals via the determination of oxygen isotope effects. Measurements of the variation in O-16 and O-18 ratios from natural abundance will reveal thermodynamic and kinetic factors that play a role in the interaction of dioxygen with transition metal reagents. Changes in oxygen bonding during redox processes are important in industrial oxidations and in biological utilzation of O2 as an energy source. The properties of metal-O2 adducts will be investigated, and electrochemical data will be gathered to address the ability of these species to carry out C-H and O-H oxidations. Correlations between driving-force and rate will be explored for electron, proton and hydrogen atom transfer reactions. An intensive mentoring program for middle school aged females in Baltimore will build on summer workshops associated with the Maryland Science Center. After two years of centering the workshops on demonstrations, the third year will focus on crafting a biotechnology display for the science center.Oxidation processes are important in biological systems and in industrial settings. The mechanism of elemental dioxygen interacting with transition metal complexes is relevant to large scale chemistry and biochemistry. Comparing kinetic and equilibrium distributions of oxygen isotopes will provide insight into the bonding changes that accompany activation and incorporation of oxygen into metal complexes and organic substrates.