Bioreactor Organ Cultures: In Vitro Models of Valvular Remodeling and Biology

Grande-Allen 0502342该提案的目标是开发一种器官培养生物反应器系统，其中可以培养二尖瓣材料，以研究体液在瓣膜重塑中的作用。该项目将确定在器官培养瓣膜组织中重建病理反应所需的化学和机械条件。 这项研究将影响瓣膜生物学领域，并有助于心脏瓣膜疾病的预防和管理。 该项目还将通过培训研究生和本科生以及为医学生和心脏病学住院医师开发一系列教学讲座来强调教育。

Grande-Allen0502342The goal of this proposal is to develop an organ culture bioreactor system in which mitral valve materials can be cultured in order to study the humoral role in valvular remodeling. The project will establish the chemical and mechanical conditions required to recreate a pathological response in the organ cultured valve tissues. This research will impact the field of valve biology and contribute to the prevention and management of heart valve disease. The project will also emphasize education by training graduate and undergraduate students and by developing a series of instructional lectures for the medical student and cardiology residents.