US Egypt Cooperative Research: Design, Fabrication and Characterization of Titanium Implants

项目描述：该项目支持普林斯顿大学机械与航空航天工程系Winston Soboyejo博士和埃及亚历山大牙科学院Mona Marei博士的合作研究。他们计划对钛植入物的制造和特性进行研究。智力优势：最近对种植体和骨整合的研究提出了许多改进牙螺钉设计的途径；本研究将探讨新型螺钉表面的制造、设计和表征，并量化其对骨整合的影响。RGD肽将通过一种新的自组装技术，化学结合到含有激光凹槽（8和12微米宽）的Laser-LokTM （BioLok International Inc.）牙螺钉上。这一努力将结合激光沟槽表面和rgd功能化表面各自对细胞粘附和附着的积极影响。同时，将设计一个螺钉来容纳PLGA聚合物支架，允许在聚合物支架和钛螺钉的界面进行机械固定。通过铸造，CNC切割和表面处理的方法成功制造将产生所需形状的高精度植入物。设计的螺钉和表面将在动物模型中进行测试，并分析其材料性能，以及扫描电镜成像和红外分析。所有样本将通过x线影像、用于骨密度计算的双能x线吸收测定法（DEXA）、组织形态测定法和显微硬度/纳米硬度测试来量化骨整合水平。其他的微化学分析将包括扫描电镜成像和能谱分析，以揭示钙的浓度。更广泛的影响：该项目涉及在卫生领域有重要应用的材料的开发。它还包括普林斯顿大学的一名本科生的培训。该项目将在生物和材料表面改性领域开展合作。通过这个项目，将对钛植入物有正确的了解。学生之间的知识交流是该提案的优势之一。研究成果将融入PI的教学和教育活动中。该项目得到了美国-埃及联合基金项目的支持，该项目向两国的科学家和工程师提供赠款，以开展这些合作活动。

0506116SoboyejoDescription: This project supports a collaborative research between Dr. Winston Soboyejo, Department of Mechanical and Aerospace Engineering, Princeton University and Dr. Mona Marei, College of Dentistry, Alexandria, Egypt. They plan to conduct studies on the fabrication and characterization of titanium implants.Intellectual Merit: Recent research in implants and osseointegration suggests many avenues for improvement in dental screw design; this study will investigate the fabrication, design, and characterization of novel screw surfaces, and quantify the effects on osseointegration. The RGD peptide will be chemically bonded to Laser-LokTM (BioLok International Inc.) dental screws containing laser-grooves (8 and 12 micrmeter width) via a novel self-assembly technique. This effort will combine the positive effects that the laser-grooved and the RGD-functionalized surfaces have both shown individually toward cellular adhesion and attachment. In parallel, a screw will be designed to accommodate a PLGA polymer scaffold permitting mechanical fixation at the interface of the polymer scaffold and titanium screw. Successful fabrication through methods of casting, CNC cutting, and finalizing with surface treatments will produce a highly precise implant in the desired shape. The designed screws and surfaces will be tested in an animal model, and its material properties analyzed, as well as SEM imaging and IR analysis. All samples will be examined to quantify the level of osseointegration via radiograph images, dual energy X-ray absorptiometry (DEXA) for BMD calculations, histomorphometry, and microhardness/nanohardness testing. Additional analysis of the microchemistry will include SEM imaging and EDS to reveal calcium concentrations.Broader impacts: The project involves development of materials that are of important application in the health field. It also involves training of an undergraduate student at Princeton University. The project will develop collaboration in the field of bio and surface modification of materials. Proper understanding of the titanium implants will be achieved through this program. Exchange of student knowledge is one of the strength in the proposal. The research results will be integrated into the PI's teaching and educational activities. This project is being supported under the US-Egypt Joint Fund Program, which provides grants to scientists and engineers in both countries to carry out these cooperative activities.