CAREER: Understanding Acute Microvessel Hyperpermeability

0133775 Fu在这个CAREER奖下，将致力于系统地了解微血管壁控制水，分子和细胞运输的结构机制，以设计新的药物和药物输送方法。 特别是，该提案侧重于开发方法来研究VEGF诱导青蛙肠系膜中单独灌注的微血管的渗透性的机制，以及这种渗透性如何受到cAMP的影响。 该计划的教育部分侧重于举办研究教育研讨会和会议，监督研究生，开设新的研究生课程，相关的本科入门课程，并为本科生和高中生提供研究培训，包括向妇女和少数民族开展外联工作，并与华西医科大学和新加坡国立大学开展国际研究/教育合作。

0133775FuUnder this CAREER Award, efforts will be made to systematically understand the structural mechanisms of microvessel wall controlling the transport of water, molecules and cells in order to design new drug and drug delivery methods. In particular, the proposal focuses on developing approaches to investigate the mechanisms by which VEGF induces permeability of individually perfused microvessels in frog mesentery and how that permeability is influenced by cAMP. The educational component of the plan focuses on creating research education seminars and conferences, supervising graduate students, creating new graduate level courses, relevant introductory undergraduate courses and providing research training for undergraduate and high school students, including outreach efforts to women and minorities and developing international research/education collaborations with West China Medical University and the National University of Singapore.