Cyclic Loading Induced Fluid Flow Associated with Mechanotransduction in Bones

骨骼中流体流动的模拟在生物力学领域受到了极大的关注。到目前为止，已经进行了有限的研究来研究在良好控制的条件下骨的变形和流体压力。提出了一系列的实验研究，以研究骨试件在单调加载和循环加载下的响应。在实验中，骨标本被限制在橡胶膜中，使用新开发的装置封闭的全方位压力。分别测量了排水和不排水条件下的诱导变形和流体压力。在不同的应力幅值和频率下，可以得到循环荷载作用下的塑性应变和累积流体压力的发展规律。这项研究是作为应用力学(地质力学)和医学科学之间的跨学科和跨机构的研究而进行的。对载荷诱导的流体流动机制的了解将有助于更好地解释骨骼的机械感觉功能，这具有重要的临床意义。

The simulation of fluid flow in bones has received considerable attention in the field of biomechanics. Limited studies have been conducted up to date to investigate the deformation and fluid pressure of bone under well controlled conditions. A series of experimental studies is proposed to investigate the response of bone specimens under monotonic followed by cyclic loadings. In the experiment, the bone specimen is confined in a rubber membrane using an all-around pressure enclosed in a newly developed device. The induced deformation and fluid pressure are measured under drained and undrained conditions, respectively. The development of plastic strains and accumulated fluid pressure under cyclic loading will be revealed for different stress amplitudes and frequencies. The study is undertaken as a cross-disciplinary and cross-institutional research between applied mechanics (geomechanics) and medical science. The understanding of mechanisms of load-induced fluid flow would lead to a better interpretation of mechanosensory function in bones that has significant clinical implications.