Carbinolamides and N-(Hydroxybenzyl)urea Derivatives: Structure/Reactivity Correlations and Catalysis of the Aqueous Reaction

有了这个新的RUI奖，有机和大分子化学项目支持伊利诺伊州立大学化学系Richard Nagorski教授的工作。该研究项目包括研究碳酰胺和N-（羟基烷基）尿素衍生物的结构/反应性相关性和水反应的催化作用。碳酰胺是酶催化形成肽激素的中间体，N-（羟基烷基）脲参与嘌呤生成尿素。尽管这些化合物具有重要的生物学意义，但人们对它们的反应性和反应机制知之甚少。为了更好地了解这些物质的化学性质，我们将研究其水溶液反应的速率和产物与pH值和结构的关系。由于有关这些化合物的反应性的数据很少，因此这些结果将是独特的，对生化界具有广泛的兴趣。这些研究将增加我们对分子和分子系统的潜在反应机制的认识，这些分子和分子系统是重要生物过程的一部分，将对生物学，药物化学，生物化学和药理学领域产生重大影响。同样重要的是，将进行这项研究的本科生和研究生的利益。对于许多人来说，这些研究将代表他们进行科学研究的第一步，这些研究涉及的技术和方法对本科生和研究生来说都很容易获得，但也很有挑战性。这类机会将导致科学界得到更好的训练和更广泛的经验。

With this new RUI award, the Organic and Macromolecular Chemistry Program supports the work of Professor Richard Nagorski of the Department of Chemistry at Illinois State University in Normal, Illinois. The research project involves investigations of structure/reactivity correlations and catalysis in the aqueous reactions of carbinolamides and N-(hydroxyalkyl)urea derivatives. Carbinolamides are intermediates in the enzyme catalyzed formation of peptide hormones and N-(hydroxyalkyl)ureas are involved in the production of urea from purines. Despite the biological importance of these compounds, the reactivity and mechanisms by which they react are poorly understood. In order to achieve a better understanding of the chemistry of these species, the rates and products of their aqueous reactions as a function of pH and structure will be investigated. Since very little data exists concerning the reactivity of these compounds, the results will be unique and of broad interest to the biochemical community.These studies, which will increase our knowledge of the underlying reaction mechanisms of molecules and molecular systems that are a part of important biological processes, will have significant impact on the fields of biology, medicinal chemistry, biochemistry and pharmacology. Of equal importance are the benefits to the undergraduate and graduate students who will carry out this research. For many, these studies will represent their first steps into performing scientific investigations that involve techniques and methods that are accessible, yet challenging, to both undergraduate and graduate students. Opportunities of this kind will lead to a scientific community that is better trained and with a wider range of experience.