IRES: U.S.-India Fast DNA Hybridization in Microfluidic Platforms

描述：这是授予美国PI Mark Madou的国际学生研究经验（IRES）奖，将使来自加州大学欧文分校的12名研究生和本科生在印度理工学院（IITK）从事微流控平台快速DNA杂交的国际研究。所有学生参与者的研究课题是一套设计规则的理论和实验发展，用于在微流控平台上制造最快和最敏感的DNA阵列。这项研究将有助于理解DNA杂交增强机制等基本问题。潜在的化学和生物医学应用包括DNA分析、药物发现和疾病的医学相关参数的现场分析。人们对复杂和全功能系统的小型化越来越感兴趣，这些系统利用了微制造的最新发展，并承诺制造芯片上的实验室分析系统，其中各种化学过程被容纳在一个小芯片上。范围：该项目将结合美国研究人员的实验优势和印度同行的建模专业知识，为美国学生提供一个独特的机会，在一个令人兴奋的研究领域获得国际经验。科技部（DST）对该项目的支持将使交换学生成为可能，这样美国学生将在IITK获得流体学和建模经验，印度学生将在Irvine接触生物mems制造的实验工作。美国学生参与者（包括少数族裔和女性）将获得更大的文化和全球视野，并通过国际合作研究培训、网络和指导获得专业成长的机会。

0526649Madou Description: This is an International Research Experiences for Students (IRES) award to US PI Mark Madou that will enable 12 graduate and undergraduate students from the University of California, Irvine to engage in international research on Fast DNA Hybridization in Microfluidic Platforms at the premier Indian Institute of Technology, Kharagpur(IITK). The research topic for all student participants is the theoretical and experimental development of a set of design rules for the fabrication of the fastest and most sensitive DNA arrays in a microfluidic platform. This study will contribute to understanding fundamental issues such as DNA hybridization enhancement mechanisms. The potential chemical and biomedical applications include DNA analysis, drug discovery, and on-the-spot analysis of the medically relevant parameters of disease. There is growing interest in the miniaturization of complex and fully functional systems that take advantage of latest developments in microfabrication and promise the fabrication of lab-on-a-chip analysis systems in which various chemical processes are accommodated onto a small chip. Scope: This project will combine the experimental strengths of the US investigators with the modeling expertise of Indian counterparts and provide a unique opportunity for US students to gain international experience in an exciting research area. Support for this project from the Department of Science & Technology (DST) will enable an exchange of students so that US students will gain fluidics and modeling experience at the IITK and Indian students will have exposure to the experimental work in bio-MEMS fabrication at Irvine. The US student participants, which include minorities and females, will gain greater cultural and global perspective, as well as opportunities for professional growth through international cooperative research training, networking and mentoring.