Tissue specific regulation of gene expression

尽管关于干细胞用于组织再生的两极分化的公众辩论，与这些细胞的身份和层次有关的基本问题仍然没有答案。 对澳大利亚的好处将是科学的，因为它提供了对干细胞和祖细胞在分化过程中如何整合转录控制系统以及所涉及的网络的理解。 这对于未来分离和操纵这些干细胞类型以造福社区至关重要。 这项工作还将为研究生提供最先进的基因组技术以及生物信息学和实验科学之间的接口方面的培训。

Despite the polarized public debate concerning the use of stem cells for tissue regeneration, fundamental questions relating to the identity and hierarchy of these cells remain unanswered. The benefit to Australia will be scientific in terms of providing an understanding of how stem and progenitor cells integrate transcriptional control systems during differentiation and the networks that are involved. This is fundamental to the future isolation and manipulation of these stem cell types to benefit the community. The work will also provide postgraduate students with training in state of the art genomic techniques and in the interface between bioinformatics and experimental science.