CAREER: The Relationship between Material Mechanics, Cellular Mechanics, and Heart Valve Disease: An Integrated Plan for Research Discovery and Promotion of Science Literacy

这个项目的目标是描述生物材料力学特性、细胞收缩性和心脏瓣膜间质细胞出现病变表型之间的关系。该项目将更好地了解导致心脏瓣膜重塑的机械应力和相关蛋白质。从长远来看，这个项目的结果可能会导致更好的监测和预防心脏瓣膜疾病，这是一个重大的健康问题。教育目标是提高科学素养，并接触到更广泛的学生和同事。教育部分将激励并使科学家和非科学家参与终身学习。外展活动将在当地一所高中和潜在的科学家进行。开设“生物医学工程中的政治、伦理、宣传与时事”新课程。

Masters0547374The goal of this project is to describe the relationship between biomaterial mechanical properties, cellular contractility, and the emergence of a diseased phenotype in heart valve interstitial cells. This project will provide a better understanding of the mechanical stresses that result in heart valve remodeling and the proteins involved. In the long term, the results from this project may lead to better monitoring and prevention of heart valve disease, which is a significant health problem. The educational goal is to increase science literacy and reach out to a broad range of students and colleagues. The educational component will motivate and enable scientists and non-scientists to engage in lifelong learning. The outreach activities will be at a local high school and potential scientists. A new course in "Politics, Ethics, Propaganda, and Current Issues in Biomedical Engineering" will be developed.