CAREER: Arterial Flow Dynamics-Effects of Pulsatility, Compliance and Curvature

提案编号： CTS-0547434主要供应商：PAVLOS VLACHOS机构： 弗吉尼亚州职业生涯：动脉血流动力学-脉动性、顺应性和曲率的影响本研究通过开发、改进和实施最先进的实验方法，重点研究心血管系统中过渡流的体外实验建模和分析，这些方法将结合起来克服传统方法的局限性。这一开创性的努力将显着推进心血管流动，特别是流动过渡的理解。实现实验工具的独特组合，并整合三个重要的心血管参数，脉动性，血管顺应性和曲率的影响，允许建模和分析其各自的影响，以及他们的复杂的相互作用。心血管疾病历来是美国的主要死因，约占全球所有死亡人数的三分之一。心血管流动由短的、弯曲的、分支的弹性管内的复杂流体-结构相互作用控制，所述弹性管内在与传播和反射压力波相互作用的同时经历横向动态运动。由于血流动力学、内皮细胞反应和血管病理之间的关系，心血管系统的流体动力学分析是一个非常重要的课题。此外，过渡流和湍流与内皮细胞损伤和血管疾病的起源有着内在的联系。然而，尽管多年的研究，心血管流量知之甚少。该补助金的综合教育部分的目标是利用研究性学习开发一种新的工程教育模式。这一努力将重塑和重新激活课堂体验，展示现代工程的多学科特征，并刺激学生的智力增长。最终，目标是加强招聘和留住工程师，包括代表性不足的群体的成员，并激励学生致力于终身学习，推进工程和造福社会的过程。 这一目标将通过将流体力学和生物流体研究转化为从中学到本科和研究生水平的工程教育来实现。

PROPOSAL NO.: CTS-0547434PRINCIPAL INVESTIGATORS: PAVLOS VLACHOSINSTITUTION: VIRGINIA TECHCAREER: Arterial Flow Dynamics-Effects of Pulsatility, Compliance and CurvatureThis research focuses on the experimental in-vitro modeling and analysis of transitional flows in the cardiovascular system by developing, improving and implementing state-of-the-art experimental methods that will be combined to overcome the limitations of conventional approaches. This pioneering effort will significantly advance understanding of cardiovascular flows and in particular flow transition. Implementing a unique combination of experimental tools and integrating the effects of three important cardiovascular parameters, pulsatility, vessel compliance, and curvature, allows the modeling and analysis of their individual effects as well as their complex interactions. Cardiovascular disease has historically been the leading cause of death in the US and accounts for approximately one third of all deaths worldwide. Cardiovascular flows are governed by complex fluid-structure interactions within short, curved, branching, elastic tubes that undergo lateral dynamic motions while interacting with propagating and reflecting pressure waves. Analysis of the fluid dynamics in the cardiovascular system is a topic of paramount importance, because of the relationship among the hemodynamics, the endothelial cell response and the vascular pathology. Moreover, transitional and turbulent flows are intrinsically related to endothelial cell injury and the origin of vascular disease. However, despite many years of research, cardiovascular flows are poorly understood. The goal of the integrated educational component of this grant is to develop a new model for engineering education using research-based learning. This effort will reinvent and reenergize the classroom experience, demonstrate the multidisciplinary character of modern engineering and stimulate the students intellectual growth. Ultimately, the goal is to enhance recruitment and retention for engineers, including members of underrepresented groups, and to motivate the students to commit to a life-long process of learning, advancing engineering and benefiting society. This goal will be accomplished by translating fluid mechanics and biofluids research to engineering education from middle school to undergraduate and graduate level.