CAREER: Catalytic Aldimine Coupling: A Versatile Carbon-Carbon Bond Forming Reaction

该研究项目致力于氰化物催化的醛亚胺偶联反应的发展，目标是许多分子结构，包括碳环，杂环，大环，二聚体，配体，低聚物，共轭和非共轭聚合物。本课程将探讨以替代催化剂取代氰化物的可能性，并将环境与分子化学单元及课程的可持续发展（绿色化学）重点与计划发展的课程联系起来。德克萨斯农工大学化学系的米勒正在探索一套独特的由氰化物催化的反应。这种反应化学为许多新型有机产物的产生提供了希望，具有潜在的应用，包括药物，有机染料和均相催化领域。在效率和催化方面，简单的双原子氰化物阴离子是显著的，特别是与高度工程化和昂贵的贵金属催化剂相比。效率和催化的概念也是米勒教授教育活动的组成部分。通过对环境的分子观点课程，高中教师和学生在整个德克萨斯州接触到环境化学主题，包括原则，分支机构，和催化的普遍性，绿色化学的12个原则之一。环境化学写作课程为学生提供科学和可持续性的跨学科性质的额外经验。

This research project addresses the development of a cyanide-catalyzed aldimine coupling reaction, targeting a number of molecular structures, including carbocycles, heterocycles, macrocycles, dimers, ligands, oligomers, and conjugated as well as non-conjugated polymers. The potential replacement of cyanide by alternate catalysts will be explored, providing a link to the sustainability (green chemistry) focus of the environmental and molecular chemistry modules and courses planned for development.With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Stephen A. Miller, of the Department of Chemistry at Texas A&M University, is exploring a unique set of reactions catalyzed by cyanide. This reaction chemistry offers promise for the generation of many novel organic products, with potential applications including the areas of pharmaceuticals, organic dyes, and homogeneous catalysis. In the context of efficiency and catalysis, the simple, two-atom cyanide anion is remarkable, especially when compared to highly engineered and expensive precious metal catalysts. The concepts of efficiency and catalysis are also integral to the educational activities of Professor Miller. Through a course on a Molecular View of the Environment, high school teachers and students across the state of Texas are exposed to environmental chemistry topics, including the principles, ramifications, and ubiquity of catalysis, one of the 12 Principles of Green Chemistry. A writing course on Environmental Chemistry provides additional experience for students in the interdisciplinary nature of science and sustainability.