Degradation of antimicrobial agents Tylosin and Chlorotetracycline during swine waste treatment

0606986石头本项目将评估两种抗菌剂泰乐菌素和氯四环素在猪粪处理(好氧和厌氧泻湖)和厌氧序批式反应器中的去向(降解)和效果。这些化合物是两种最常用的抗菌剂，用于提高猪的生长速度，预防、控制和治疗封闭饲养场中与猪有关的健康问题。这些抗菌剂在养猪生产中的广泛使用使此类信息的开发变得及时而重要。该项目有四个研究目标：(1)通过基于实验室的好氧和厌氧泻湖废物处理过程的模拟来确定抗生素的去除效率；(2)评估抗生素对嗜冷性(约5-20oC)和中嗜性(约30-38oC)好氧和厌氧泻湖处理性能的影响；(3)量化在好氧和厌氧废物处理过程中由于抗生素而导致的微生物群落多样性和活性的变化；以及(4)确定在猪粪便处理过程中由于抗生素而导致厌氧序批式反应器(SBR)运行效率的变化。该项目更广泛的影响部分涉及南达科他州两所大学之间的合作以及本科生和研究生参与研究。

0606986 Stone This project will evaluate the fate (degradation) and effects of two antimicrobials, tylosin and chlorotetracycline (CTC), in swine manure treatment (aerobic and anaerobic lagoons) and anaerobic sequencing batch reactors. These compounds are two of the most commonly administered antimicrobial agents to improve swine growth rates and prevent, control, and treat swine-related health problems in confined feedlots. The pervasive use of these antimicrobials in swine production makes the development of such information timely and important. The project has four research goals: (1) determine removal efficiencies of the antibiotics through laboratory based simulations of aerobic and anaerobic lagoon waste treatment processes; (2) assess the impacts of the antibiotics on psychrophilic (ca. 5-20oC) and mesophilic (ca. 30-38oC) aerobic and anaerobic lagoon treatment performance; (3) quantify changes in microbial community diversity and activity due to the antibiotics during aerobic and anaerobic waste treatment; and (4) determine changes in operational efficiency of anaerobic sequencing batch reactors (SBR) due to the antibiotics during treatment of swine waste. The broader impacts section of the project involves collaboration between two universities in South Dakota and participation by undergraduates and graduate students in the research.