Visualisation of herpes virus infections and immune responses as well as their modulation (B01)

B1项目的目的是更好地了解免疫细胞和病毒感染细胞之间的相互作用以及感染细胞如何在体内被杀死。在上一个资助期内，我们研究了CD8+ T细胞和NK细胞在淋巴结和皮肤中的杀伤能力，并比较了MCK-2精通和缺乏MCMV在新生小鼠肺部的病毒趋向性。在下一个资助期，我们的目标是了解细胞毒性CD8+ T细胞和NK细胞在杀死病毒感染细胞中的异质性和协同性。此外，我们的目标是破译髓细胞在感染细胞周围创造环境的作用，这有助于控制病毒向邻近细胞的传播。

The aim of the project B1 is to better understand interactions between immune cells and virus-infected cells and how infected cells get killed in vivo. In the last funding period we investigated the killing capacities of CD8+ T cells and NK cells in lymph nodes and skin and compared the viral tropism of MCMV proficient and deficient for MCK-2 in lungs of neonatal mice. In the next funding period, we aim to understand the heterogeneity and cooperativity of cytotoxic CD8+ T cells as well as NK cells in killing virus-infected cells. Furthermore we aim to decipher the role of myeloid cells in creating an environment around infected cells that contributes control virus-spread to neighboring cells.