Interaction between hepatitis C virus and lipoproteins and its role for infection and viral persistence (A06)

50%至90%的丙型肝炎病毒（HCV）感染呈慢性病程。病毒与脂蛋白的结合可能通过直接影响病毒进入肝细胞以及通过抗体保护而导致持久性。载脂蛋白E（ApoE）多态性与HCV感染的不同病程相关。因此，我们阐明了介导HCV脂蛋白相互作用的机制，我们剖析了病毒相关脂蛋白对HCV细胞进入的作用，并研究了体内HCV脂蛋白相互作用的变异性。这些目标旨在分析介导与脂蛋白相关的病毒和宿主因素，并确定其对病毒持久性的作用。

Fifty to 90% of hepatitis C virus (HCV) infections take a chronic course. The association of the virus with lipoproteins may contribute to persistence via a direct influence on virus entry into liver cells and in addition through protection from antibodies. Apolipoprotein E (ApoE) polymorphisms are associated with a different course of HCV infection. Therefore, we elucidate the mechanisms that mediate HCV lipoprotein interaction, we dissect the role of virus-associated lipoproteins for HCV cell entry and we investigate the variability of HCV lipoprotein interaction in vivo. These goals aim at analysing viral and host factors that mediate association with lipoproteins and to define their role for virus persistence.