SBIR Phase I: Molecular Design of Advanced Monolayers For Improved Surface Amination

这个小型企业创新研究(SBIR)第一阶段项目寻求满足特定表面功能的先进单分子层领域的需求。该项目致力于解决阻碍许多新型生物传感器、实验室芯片和生物微机械进入市场的一个关键限制因素，即用于将生物分子耦合到界面的化学物质。氨基丙基三甲氧基硅烷(APTMS)是当今最常用的连接化学，它被广泛应用于从色谱柱的固定相到DNA实验室芯片，再到化学传感器。然而，对这种分子(以及它形成的分子层(S))的控制和操纵仍然是不够和有限的。目前的提议旨在为从新型前体衍生的端胺分子层找到新的合成路线。这反过来可能导致下一代先进传感器、生物分析设备、DNA芯片和其他医疗诊断/治疗技术的发展。

This Small Business Innovation Research (SBIR) Phase I project seeks to fill a need in the arena of advanced monomolecular layers for specific surface functionalities. The project addresses a key limiting factor which prevents many novel biosensors, labchips and BioMEMS from reaching the market, i.e. the chemistry used for coupling biomolecules to interfaces. Aminopropyltrimethoxysilane (APTMS) is the most commonly used linking chemistry today, and it is being used in a wide variety of applications from stationary phases in chromatographic columns, to DNA labchips, to chemical sensors. The control and manipulation of this molecule (and molecular layer(s) it forms), however, remains insufficient and limited. The current proposal aims to arrive at new synthetic routes for amine-terminated molecular layers derived from novel precursors. This could, in turn, lead to the development of next-generation advanced sensors, bioassay devices, DNA chips and other medical diagnostic/therapeutic technologies.