RUI: Oxadiazines-Structurally Novel Templates for Catalytic Asymmetric Syntheses

本项目的重点是开发一类结构新颖的杂环，恶二氮类，作为手性助剂。具体目标包括：(1)三个不同亚基的恶二嗪的合成；(2)恶二氮类化合物在三种不对称反应中的应用；(3)组胺H3拮抗剂GT-2331的合成。通过这一奖项，有机化学和高分子化学计划以及扩大参与STEM的联盟(ABP)支持伊利诺伊州立大学化学系肖恩·R·希区柯克教授的研究。希区柯克教授的研究工作围绕不对称合成新反应的开发展开。该项目对制药业具有相当重要的意义，因为它可能会影响药物的制备方式。

This project is focused on the development of a structurally novel class of heterocycles, oxadiazines, as chiral auxiliaries. The specific objectives include: (1) the synthesis of three different sub-groups of oxadiazines; (2) application of the oxadiazines in three different types of asymmetric reactions; (3) the synthesis of the histamine H3 antagonist GT-2331. With this award, the Organic and Macromolecular Chemistry Program and the Alliances for Broadening Participation in STEM (ABP) are supporting the research of Professor Shawn R. Hitchcock, of the Department of Chemistry at Illinois State University. Professor Hitchcock's research efforts revolve around the development of new reactions for asymmetric synthesis. The project is of considerable significance to the pharmaceutical industry, as it could impact how medicines are prepared.