CAREER: Versatile Vanadium: Materials Science, Biology, and Education Through Its Diverse Coordination Chemistry

该职业奖由无机、生物无机和有机金属化学项目颁发，支持伊利诺伊州立大学Craig C. mclacchlan博士对钒与三齿蝎子酸配体的配位化学和反应性的研究。这些研究将阐明这些配合物的合成方法，并检查它们在材料、催化和治疗性药物应用中的反应性和性质。所提出的研究应该揭示新的钒-有机膦酸盐配合物，并提供通过配体选择控制维度的见解。通过扩大对生理条件下钒配合物的主要氧化状态的个体因素的理解，提出的工作为钒配合物作为药物治疗剂的利用提供了额外的见解。这个项目的教育部分包括为一系列逐渐复杂的配位化学课程创建教育模块，这些课程涉及学生反应装置（又名学生反应装置）。“遥控器”)技术。麦克劳克伦教授还将纳入模型套件，以提高学生对分子水平结构的理解。他将建立一个指导网络，为感兴趣的社区大学教师提供讲习班和免费使用学生反馈系统。麦克劳克伦教授还将在教学/研究实验室指导学生，为他们提供合成、表征和x射线训练方面的广泛技能，为学生将来在工业或研究生院的工作做好准备。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports research by Dr. Craig C. McLauchlan at Illinois State University on the coordination chemistry and reactivity of vanadium with tridentate scorpionate ligands. The studies will elucidate synthetic methodologies in the preparation of these coordination complexes and examine their reactivities and properties for use in materials, catalysis, and therapeutic medicinal applications. The proposed studies should reveal novel vanadium-organophosphonate complexes and offer insight in control of dimensionality through ligand choice. The proposed work offers additional insight into the utilization of vanadium complexes as medicinal therapeutic agents by expanding the understanding of individual factors in the dominant oxidation states of these complexes under physiological conditions. The educational component of this project involves the creation of educational modules for a series of progressively complex classes on the subject of coordination chemistry involving Student Response Device (a.k.a. "clicker") technology. Professor McLauchlan will also incorporate model kits for use in improving student understanding of molecular-level structure. He will establish a mentoring network and offer workshops and free use of a student response system to interested community college faculty. Professor McLauchlan will also mentor students in the teaching/research laboratory, providing them with a broad skill set in synthesis, characterization, and X-ray training, which will prepare the students well for their futures in industry or graduate school.