Synthesis of dihydropyrans by a tandem Suzuki/Michael reaction

通过这一奖项，有机化学和高分子化学项目支持巴特勒大学的卢安·麦克纳尔蒂教授的工作。本研究致力于通过新的、收敛的合成方法来合成二氢吡喃。这些化合物的亚结构存在于许多天然产物中，其中一些具有有趣的生物活性。麦克纳尔蒂博士和他的同事将使用微波技术来辅助这些合成。更广泛的影响：这项研究的更广泛的影响被认为是突出的，因为所有参与项目的学生都是本科生。这些学生将从事前沿研究，并将被鼓励在会议上展示他们的工作。因此，对从事这些项目的本科生的培训和教育将通过至少两个途径为社会做出宝贵贡献：增加更多训练有素、技能更高的科学家；发现新的合成方法，以制备可能具有有用药用特性的化合物。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor LuAnn McNulty from Butler University. This research is focused on the syntheses of dihydropyrans via novel and convergent synthetic methods. Substructures of these compounds are found in manynatural products, some of which have interesting biological activities. Dr. McNulty and coworkers will use microwave technology to assist in these syntheses. Broader Impacts: The Broader Impacts of this research is considered to be outstanding, as all of the students working on the projects are undergraduates. These students will be doing cutting edge research, and will be encouraged to present their work at conferences. Thus, the training and education of the undergraduate students working on these projects will provide a valuable contribution to society via at least two avenues: an increase in more highly trained and skilled scientists; and the discovery of new synthetic methods to prepare compounds that may have useful medicinal properties.