SBIR Phase I: Polarization-diverse leaky-mode resonance biosensors in compact format

这个小型企业小型企业创新研究（SBIR）第一阶段研究项目旨在开发一类新的生物传感器，该传感器基于薄周期膜中的导模共振效应，以监测完整的生化结合事件，而无需外来标签。谐振传感器在没有化学标签的情况下工作的事实允许观察和研究未受干扰的生化过程，因为不需要引入外来物质。因此，这些传感器可以增强对化学和生物分子过程的理解，并可能导致化学过程开发，药物发现和国防应用的进步。所提出的新型传感器可能对医疗诊断、药物开发、蛋白质组学、基因组学、环境监测和国土安全等领域产生重大影响。

This Small Business Small Business Innovation Research (SBIR) Phase I research project aims to develop a new class of biosensors based on the guided-mode resonance effect in thin periodic films to monitor complete biochemical binding events without foreign tags. The fact that the resonant sensors operate without chemical tags permits observation and study of unperturbed biochemical processes, as no foreign substance needs to be introduced. Therefore, these sensors can provide enhanced understanding of chemical and bio-molecular processes and may lead to advances in chemical process development, drug discovery, and defense applications. The new class of sensors proposed could have high impact on areas such as medical diagnostics, drug development, proteomics, genomics, environmental monitoring, and homeland security.