Electrically Controlled Neurochemical Delivery System

本项目的主要目标是实现一种电活性控制的导电聚合物药物释放装置。该系统将利用电活性导电聚合物的独特性质，该聚合物可以通过与离子药物分子结合的电聚合来合成，从而允许将柔性药物装载到电极上。在电势变化时，聚合物经历氧化还原反应，导致药物从电极释放，释放量由电刺激的幅度控制。该项目的具体目标是：（1）基于传导蛋白的神经化学系统的体外开发和表征，以及（2）神经化学传递系统的体内表征。 跨学科研究项目包括生物工程，材料科学和神经科学的元素。这项研究将为神经电极接口领域做出重要贡献，支持新课程开发，培训研究生和本科生，并支持教育妇女和少数民族的计划。研究结果将加强多学科领域的科学认识。该项目将显著影响局部药物输送，同时实时记录神经反应。

0729869CuiThe main objective of this project is to implement an electroactively controlled conductive polymer drug release device. The system will utilize the unique properties of electroactive conducting polymers, which can be synthesized by electropolymerization with ionic drug molecules incorporated, allowing for flexible drug loading onto electrodes. Upon an electrical potential change, the polymer undergoes redox reactions that lead to the release of drug from the electrodes, with the release quantity controlled by the amplitude of electrical stimulation. The specific aims of the project are: (1) in-vitro development and characterization of a conductin-based neurochemical system, and (2) in-vivo characterization of the neurochemical delivery system. The interdisciplinary research project includes elements of bioengineering, material science and neuroscience. This study will make important contributions to the field of neuro-electrode interfacing.The research will support new course development, train graduate and undergraduate students and support programs for educating women and underrepresented minorities. The results will enhance scientific understanding in multi-disciplinary fields. This project will significantly impact localized drug delivery while electrically recording the neural response in real-time.