CAREER: Synthetic Co-Hosts for Sequence-Specific Recognition and Labeling of Peptides in Aqueous Solution

三一大学化学系的Adam Urbach教授因其研究涉及识别和标记水溶液中特定多肽的分子而得到有机和高分子化学计划的支持。这类化合物将对从基础生物化学到医学诊断和治疗学等领域产生广泛影响。目前的方法综合起来具有挑战性，因此效率低下。PI计划开发一种修改合成肽受体的方法，使其设计、合成和表征能够快速迭代，从而大大加快发现过程。该项目的教学部分重点是将本科生和博士后纳入研究，并加强三一学院的教学和研究一体化，重点是写作和实验设计技能。

Professor Adam Urbach, of the Department of Chemistry at Trinity University, is supported by the Organic and Macromolecular Chemistry Program for his research involving the design of molecules that recognize and label specific peptides in aqueous solution. Such compounds would have broad impact on fields ranging from basic biochemistry to medical diagnostics and therapeutics. Current approaches are synthetically challenging and thus inefficient. The PI plans to develop an approach to modifying synthetic peptide receptors that will enable rapid iteration of their design, synthesis, and characterization, thus substantially accelerating the discovery process. The teaching portion of the project focuses on incorporating undergraduate and postdoctoral students in the research, and on improving the integration of teaching and research at Trinity, with a focus on writing and experimental design skills.