CAREER:The Physics of Signaling in Cell Membranes: Phosphoinositides and Small GTPases as a Paradigm.

技术概要：该职业奖支持细胞膜信号分子物理学的教育、理论和计算研究。该研究涉及多尺度的理论和计算建模。基本的基础 描述脂质与蛋白质和蛋白质与蛋白质的相互作用，并最终了解这些相互作用如何在整个细胞水平上决定细胞功能。拟议的工作将包括原子水平分辨率的肽磷脂相互作用的调查。在这个层面上的理解提供了输入的描述磷脂-蛋白质和蛋白质-蛋白质的相互作用的粗粒度模型。在最先进的阶段，这项工作然后扩展这些粗粒度的蛋白质和脂质模型，以研究流体动力学相互作用。该奖项支持相关的教育活动，通过将本科生和研究生融入研究过程，促进教学，培训和学习。 这项研究将通过研讨会和其他正式和非正式的互动，为支持爱荷华州K-12社区教育的外联活动提供信息。其中将包括与当地高中合作，利用计算方法加强科学教育，使学生能够使用计算机模型模拟自然过程。通过让研究生和本科生参与到研究中来，这项工作也将提供基于尖端科学的计算机建模能力的教育，从而提高学生的教育和专业技能。非技术概述：该职业奖支持活细胞与环境相互作用机制的分子物理学的教育，理论和计算研究。该研究旨在了解物质和信息的运输，通过细胞膜中发生的复杂过程进出细胞。 该研究涉及多尺度的理论和计算建模，研究形成膜的单个分子和进行信号传导的蛋白质，然后建立对信号传导和运输过程如何在整个细胞水平上与细胞功能一起工作的更普遍的理解。该奖项支持相关的教育活动，通过将本科生和研究生融入研究过程，促进教学，培训和学习。 这项研究将通过研讨会和其他正式和非正式的互动，为支持爱荷华州K-12社区教育的外联活动提供信息。其中将包括与当地高中合作，利用计算方法加强科学教育，使学生能够使用计算机模型模拟自然过程。通过让研究生和本科生参与研究，学生在大学一级，这项工作也将提供教育的前沿科学为基础的计算机建模能力，从而提高学生的教育和专业技能。

TECHNICAL SUMMARY:This CAREER award supports education, and theoretical and computational research on the molecular physics of signaling in cell membranes. The research involves theoretical and computational modeling at multiple scales. The fundamental underpinnings describe lipid-protein and protein-protein interactions with an ultimate view of understanding how these enter into the determinations of cell functions at the whole cell level. The proposed work will consist of investigation of peptide-phospholipid interactions with atomic level resolution. The understanding at this level provides input for the description of phospholipids-protein and protein-protein interactions by coarse-grained models. In the most advanced stages, this work then takes up extending these coarse-grained models of proteins and lipids to investigate hydrodynamic interactions. The award supports related educational activities that promote teaching, training and learning via integration of undergraduate and graduate students into the research process. The research will inform outreach activities supporting education in Iowa K-12 communities through workshops and other formal and informal interactions. Among these will be the involvement with local high schools to enhance science education with computational methods giving students capabilities of computer models of natural processes. By engaging graduate and undergraduate students in research, students at the university level, this work will also be providing education in cutting edge scientific based computer modeling capabilities and so enhance student education and professional skills.NON-TECHNICAL SUMMARY:This CAREER award supports education, and theoretical and computational research on the molecular physics of the mechanisms employed by living cells to interact with the environment. The research is motivated to understand transport of materials and information, into and out of a cell, through complex processes occurring in the cell membrane. The research involves theoretical and computational modeling at multiple scales, taking studies of individual molecule that form the membranes and the proteins that carry out the signaling and then building up to more general understanding of how signaling and transport processes work with cell functions at the whole cell level. The award supports related educational activities that promote teaching, training and learning via integration of undergraduate and graduate students into the research process. The research will inform outreach activities supporting education in Iowa K-12 communities through workshops and other formal and informal interactions. Among these will be the involvement with local high schools to enhance science education with computational methods giving students capabilities of computer models of natural processes. By engaging graduate and undergraduate students in research, students at the university level, this work will also be providing education in cutting edge scientific based computer modeling capabilities and so enhance student education and professional skills.