Frequenzdynamik epileptischer Netzwerke: Eine systemneurophysiologische Funktionsanalyse

该研究的主要目的是一种新的非侵入性替代标记物，用于癫痫网络的定位和理解。癫痫发作活动和癫痫发作之间出现的尖峰是癫痫网络的特征。这些信号的源分析有助于例如癫痫手术的规划。目前的研究提出了新的标志物：高（“高频振荡”- HFO）和低频振荡（“慢波”）。这些分析使得癫痫网络的定位和调查及其独立于尖峰和癫痫发作的时间动态。因此，即使在没有尖峰（约20-30%）和不需要癫痫发作的患者中，也可以获得此类信息。HFO与癫痫网络密切相关，这保证了更准确的定位。迄今为止，研究主要是使用侵入性方法进行的，这限制了临床应用。目前的研究旨在同时采用有创和无创方法研究HFO/慢波。为此，同时侵入性/表面脑电图和MEG记录在耐药性局灶性癫痫患者。活动在高，低频段的本地化和比较的金标准，长期侵入性脑电图和切除量癫痫手术后。与从健康对照获得的标准进行定量比较。

The main aim of the study is a new non-invasive surrogate marker for localization and understanding of epileptic networks. Seizure activity and between seizures occurring spikes are characteristic for epileptic networks. Source analysis of these signals contributes for example to the planning of epilepsy surgery. Current studies now suggest new markers: high- (“high frequency oscillations” – HFO) and low-frequency oscillations (“slow waves”). Analysis of these enables localization and investigation of epileptic networks and their temporal dynamics independent of spikes and seizures. Therefore, even in patients without spikes (~20-30%) and without the need of seizures such information can be obtained. HFO are strongly correlated with epileptic networks, which promises more accurate localizations. So far, studies were mainly conducted using invasive methods, which limits clinical application. The presented study now aims to investigate HFO/slow wave with simultaneous invasive and non-invasive methods. For this purpose, simultaneous invasive-/surface-EEG and MEG is recorded in patient with pharmacoresistant focal epilepsies. Activity in high- and low-frequency bands is localized and compared with the gold-standard of long-term invasive EEG and resection volume after epilepsy surgery. A quantitative comparison is performed with the norm, acquired from healthy controls.