Analytischer Nachweis von diabetischen Stoffwechselentgleisungen insbesondere bei forensischen Fragestellungen (Hypoglykämien im Zusammenhang mit Überdosierungen mit humanen Insulinen, synthetischen Insulinanaloga oder oralen Antidiabetika)

在发达国家，糖尿病是第七大常见死因。由于缺乏特征性的形态学表现，尸检诊断葡萄糖代谢紊乱是困难和模糊的。这些疾病经常发生，并代表着一种危险，例如交通出勤。此外，在许多情况下，法医病理学家可能无法证明明确的生化或组织学证据高血糖或低血糖。本研究的目的是分析检测糖尿病代谢紊乱的生前和死后。这意味着在过量使用人或合成胰岛素或口服降糖药后检测到低血糖。除此之外，还研究了明确确定高渗血症（酮症酸中毒或高渗性昏迷）的参数。

In developed countries diabetes is the seventh most common cause of death. Post mortem diagnosis of glucose metabolism disorders can be difficult and vague caused by the missing of characteristic morphological findings. These disorders happen quite often and represent a danger for example for traffic attendance. Furthermore, in many cases the forensic pathologist may not be able to demonstrate unequivocal biochemical or histological proof for hyperglycaemia or hypoglycaemia. Aim of this study is the analytical detection of diabetic metabolism disorders ante and post mortem. This implies the detection of hypoglycaemias after overdoses with human or synthetic insulins or oral antidiabetics. In addition to that, parameters for the unequivocal determination of a hyperglycaemia (ketoacidosis or hyperosmolar coma) are investigated.