Simulation of Microdamage in Cancellous Bone on the Basis of Micro-computed Tomography

骨是一种能够自我修复的活组织。在日常加载条件下，发生微损伤。有时候，骨骼无法足够快地修复这种损伤。在这些情况下，骨折。这是老年人骨质疏松的一个众所周知的现象。为了更好地了解微损伤的发展和传播，模拟有助于找出不同参数的影响。本研究的目的是开发一种有限元方法，使用ABAQUS来模拟松质骨中的微损伤，并预测受损松质骨的断裂行为。这将以东道机构以前的研究为基础。因此，不同供体的松质骨立方体将用显微计算机断层扫描。在扫描的3D重建的基础上，将生成有限元网格。之后，立方体将被压缩与定义的负载。在下一步中，探针将用铅-醋酸双氧铀染色并再次扫描。模拟的结果将与受损立方体的微计算机断层扫描的3D重建进行比较。最后，将考虑供体的年龄和性别来分析实验和模拟的结果。在这种方法的基础上，有可能描述植入物对骨微损伤的影响。

Bone is a living tissue which is able to repair itself. Under daily loading conditions microdamage occurs. Sometimes the bone is not able to repair this kind of damage fast enough. In these cases the bones fracture. This is a well known phenomenon in osteoporotic bones of the elderly population. To get a better understanding of the development and propagation of microdamage simulations are helpful to find out the influence of different parameters. The aim of this research fellowship is to develop a finite element method using ABAQUS to simulate microdamage in cancellous bone and predict the fracture behaviour of damaged osteoporotic bone. This will base on former studies of the host institution. Therefore cancellous bone cubes of different donors will be scanned with micro-computed tomography. On the basis of the 3D reconstruction of the scans finite element meshes will be generated. Afterwards the cubes will be compressed with defined loads. In the next step the probes will be stained with lead-uranyl acetate and scanned again. The results of the simulations will be compared with the 3D reconstructions of the micro-computed tomography of the damaged cubes. Finally the results of the experiments and of the simulations will be analyzed considering the age and the sex of the donor. On the basis of such methods it is possible to describe the influence of implants on the microdamage of bones.