Next Generation Ligand Architectures: Design, Development, Application and Chiral Variants

这个无机、生物无机和有机金属化学项目的研究奖支持密西西比大学T. Keith Hollis教授在设计和开发下一代配体结构方面的工作。该计划特别侧重于寻求新开发系统的突破。最近的发展导致了一类新的过渡金属ccc - n -杂环碳（CCC-NHC）配体的展示。在奖励期间，将研究过渡金属配合物的合成方法。配体独特的空间和电子性质在碳氢活化、二氮活化和光捕获等方面具有潜在的应用前景，通过适当的合成方法可以制备所需的金属配合物。配体的早期和晚期过渡金属配合物在C-C、C-N、C-Si和C-B成键反应中表现出新的反应活性。这些反应和其他反应的范围和局限性将在项目期间进行调查。在本课程中发展的基本有机金属化学将应用于具有社会和经济影响的研究问题-药物合成的新方法和光催化的光收集与水分解的潜力。这项研究将招收本科生、研究生和博士后，为他们提供有机化学和有机金属化学合成方法以及催化方面的培训和经验。新配体结构的发展对制药科学、催化、电致发光和光催化具有重要意义。为了实现这些应用，需要新的配体设计，需要新的合成方法。新配合物的催化试验为改进系统的设计提供反馈。创新的新配体通过使化学过程在经济上更可行和通过实现以前无法获得的反应模式来影响社会。

This research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor T. Keith Hollis at The University of Mississippi in the design and development of next generation ligand architectures. This program specifically focuses on seeking breakthroughs with newly developed systems. Recent developments have led to the demonstration of a novel class of CCC-N-heterocyclic carbene (CCC-NHC) ligands for transition metals. The synthetic methods for the development of transition metal complexes of the ligands will be investigated during the award period. The unique steric and electronic properties of the ligands have potential for applications in C-H activation, dintirogen activation, and light harvesting, with appropriate synthetic methodologies to prepare the needed metal complexes. The early and late transition metal complexes of the ligands show novel reactivity in C-C, C-N, C-Si and C-B bond forming reactions. The scope and limitations of these reactions and others will be investigated during the project. The fundamental organometallic chemistry developed in this program will be applied to research problems with societal and economic impact - new methods for pharmaceutical synthesis and light harvesting for photocatalysis with potential for water splitting. This research will engage students at the undergraduate, graduate and postdoctoral level, providing them with training and experience in the synthetic methods of organic and organometallic chemistry and in catalysis. The development of new ligand architectures has implications for pharmaceutical science, catalysis, electroluminescence, and photocatalysis. To achieve these applications, new ligand designs that demand new synthetic methods are required. Catalytic tests of the new complexes provide feedback into the design of improved systems. Innovative new ligands impact society by making chemical processes economically more viable and by achieving reactivity patterns that were not previously accessible.