INTERNATIONAL - Isotopic Perturbation of Methyl Rotation in Carbocations

可能是最重要的主题下进行调查，这项补助金是拟议的新扩展的核磁共振同位素扰动方法（起源于桑德斯实验室，并已应用于许多问题，涉及碳阳离子结构和重排）的情况下，旋转的甲基是同位素扰动。 这项创新将在碳阳离子领域之外有许多重要的应用。 预计这种方法将用于探测在小于三重对称的环境中与甲基基团的非等价CH键的细微差异。 更广泛的影响是由来自克罗地亚和耶鲁大学的学生（包括妇女）的参与的期望。 预计参与这项赠款支持的工作将对他们的教育有很大帮助。

Probably the most important topic to be investigated under this grant is the proposed new extension of the NMR isotopic perturbation method (which originated in the Saunders Laboratory and has been applied to many problems involving carbocation structures and rearrangements) to cases where the rotation of a methyl group is isotopically perturbed. This innovation will have a number of important applications outside of the field of carbocations. It is expected that this method will be used to probe subtle differences on the non-equivalent CH bonds to methyl groups in environments of less than three-fold symmetry. The broader impacts are addressed by the expectation of having student involvement (including women) from Croatia and from Yale. It is expected that participation in the work supported by this grant would be a substantial aid to their education.