MRI: Acquisition of Tri-Institutional, Cyber-Enabled Chemistry MALDI-TOF Mass Spectrometer

获得主要研究仪器项目（MRI）的这一奖项后，宾夕法尼亚大学的Ivan J. Dmochowski将获得一个矩阵辅助激光解吸电离飞行时间（MALDI-TOF）质谱仪，该质谱仪将与位于西费城的两所邻近大学（德雷克塞尔大学和费城科学大学）的研究人员共享网络配置。该仪器将用于涉及中高分子量生物和合成分子的研究。具体的例子有低聚-蒽环类络合、化学选择性连接和控制寡聚反应的研究、用于研究生物大分子有机合成的复杂生物系统的化学工具的开发以及细菌蛋白质表达。三所参与机构的化学和生物化学专业的本科生和研究生将能够进行学年和夏季研究。maldi - tof质谱法是获得非常大分子精确分子量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱仪已成为一种标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。

With this award from the Major Research Instrumentation program (MRI), Ivan J. Dmochowski from the University of Pennsylvania will acquire a matrix-assisted laser desorption ionization, time-of-flight (MALDI-TOF) mass spectrometer that will be shared in a cyber-enabled configuration with researchers at two neighboring universities in West Philadelphia, Drexel University and University of the Sciences in Philadelphia. The instrumentation will be used for research involving biological and synthetic molecules of mid-high molecular weights. Specific examples are studies of oligo-anthracycline complexing, chemoselective ligations and controlled oligomerization reactions, development of chemical tools for studying complex biological systems for study of organic synthesis of biomacromolecules, as well as bacterial protein expression. Undergraduate and graduate students from chemistry and biochemistry majors at the three participating institutions will be able to conduct academic-year and summer research.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights of very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.