Collaborative Research: Center for Pharmaceutical Manufacturing and Formulation

药物制造和配方I/UCRC计划资助0832469佐治亚理工学院；Andreas Bommarius 0832530堪萨斯大学；Eric Munson 0832478 Duquesne University；乔治亚理工学院、堪萨斯大学和杜肯大学提议为一个合作中心“药物制造和配方中心（CPMF）”提供规划资助，以解决制药行业当前面临的挑战，旨在开发更具选择性和更强大的制造工艺、更稳定的配方、更好的特性和一致性产品的解决方案。该中心将为来自政府、学术界和工业界的科学家之间的合作项目提供一个机制，以开发创新的方法，实现更有选择性和更强大的过程，减少环境足迹，并提高国家药品供应的安全性。拟议的研究议程包括制造、配方和分析。制造的重点是从目前的批量工艺规范过渡到微尺度和连续工艺。将检测和快速识别假药和降解药物的方法的制造、配方和分析结合起来，将导致该领域知识的进步。这些领域的进步将有助于降低生产成本，并有助于保持公司的生存。拟议的工作将提高开发安全药物和药物配方的能力。与制药业的合作将通过促进技术和信息的迅速传播和应用而增加价值。拟议的中心（CPMF）将促进参与学生在进行研究时的学习。CPMF还将强调在研究生教育中招募代表性不足的群体，包括对服务于代表性不足群体的学院和大学进行演讲和访问，特别是那些教师是校友的大学。

Planning Grant for an I/UCRC for Pharmaceutical Manufacturing and Formulation 0832469 Georgia Tech; Andreas Bommarius 0832530 University of Kansas; Eric Munson 0832478 Duquesne University; James Drennen Georgia Institute of Technology, University of Kansas, and Duquesne University propose a planning grant for a collaborative center "Center for Pharmaceutical Manufacturing and Formulation (CPMF)" to address current challenges in the pharmaceutical industry with the aim of developing solutions towards more selective and robust manufacturing processes, more stable formulations, and better characterized and consistent products. The Center will provide a mechanism for collaborative projects between scientists from government, academia, and industry to develop innovative methods towards more selective and robust processes with less environmental footprint and to improve the safety of the nations drug supply. The proposed research agenda includes manufacturing, formulation, and analytical. The manufacturing focus is on transitioning to microscale and continuous process from the current norm of batch processes. The integration of manufacturing, formulation, and analyses of the approaches to testing and rapid identification of counterfeit and degraded drugs will lead to an advancement in knowledge in the field. Advances in these areas would help mitigate production costs, and would help keep the companies viable. The proposed work will improve the ability to develop safe drugs and drug formulations. Collaborations with the pharmaceutical industry will add value by promoting the rapid dissemination and application of technologies and information. The proposed center (CPMF) will promote learning by participant students as they conduct their research. CPMF will also place emphasis on recruiting under-represented groups in the graduate education, including presentations and visits to colleges and universities that serve under-represented groups, especially where the faculty are alumni.