CAREER: Oxidative Cross-Coupling--An Efficient and Green Method for Synthesizing Biaryls

本项目将开发新的氧化交叉偶联反应用于合成联芳基分子，并将测试这一新过程的机制假设。这项工作的主要目标是建立一个模型来解释所观察到的现象，并可用于预测给定芳基底物的理想反应条件。系统的竞争和动力学研究将用于探索反应机理，从这些实验中收集的信息将用于开发新的氧化偶联反应。有了这个奖项，有机和大分子化学项目支持了罗德岛大学化学系Brenton DeBoef教授的研究。DeBoef教授的研究工作集中在发明新的化学反应上，这种化学反应可以分裂强碳氢键，一步形成新的碳碳键。这些新工艺可能简化高价值分子的合成，如药物、除草剂和有机发光二极管染料。此外，与许多现有技术相比，这些新反应对环境的影响更小。DeBoef博士也在开发新的研究型课程，包括多步骤化学合成和绿色化学。本科生和研究生正在接受全球市场合成化学家职业培训，并将受益于DeBoef博士在罗德岛大学开发的国际化学项目。

This project will develop new oxidative cross coupling reactions for the synthesis of biaryl molecules and will test a mechanistic hypothesis for this novel process. The primary goal of the work is the development of a model that explains the observed phenomena and can be used to predict the ideal reaction conditions for a given aryl substrate. Systematic competition and kinetic studies will be used to probe the reaction mechanism, and the information gleaned from these experiments will be used to develop new oxidative coupling reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Brenton DeBoef of the Department of Chemistry at the University of Rhode Island. Professor DeBoef's research efforts are focused on the invention of new chemical reactions that cleave strong carbon-hydrogen bonds and form new carbon-carbon bonds in a single step. These new processes may streamline the synthesis of high-value molecules such as drugs, herbicides, and dyes for organic light emitting diodes. Additionally these novel reactions have less environmental impact than many of the existing technologies. Dr. DeBoef is also developing new research-oriented curricula involving multi-step chemical synthesis and green chemistry. Undergraduate and graduate students are being trained for careers as synthetic chemists in the global marketplace, and will benefit from the International Chemistry Program that Dr. DeBoef is developing at the University of Rhode Island.