CAREER: Mesoscale Self-Assembly of Hydrophilic Materials

ID：MPS/DMR/BMAT（7623）0847287 PI：Khademhosseini，Ali 布里格姆&女子医院标题：职业：亲水材料的中尺度自组装该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。智力优势：产生具有空间组织化学，生物和机械性能的生物相容性材料的能力有利于广泛的应用。 提出了一种通过预制形状控制的微凝胶的自组装来制备这种材料的有效方法。 在这个提议中，一个可扩展的方法来指导介观尺度的亲水性材料的自组装将开发通过使用多相系统的热力学原理和微工程技术。 为了实现这一目标，将使用两步自下而上的方法，其中微凝胶最初组装，随后通过交联反应稳定。 水和油界面处的表面张力沿着与锁和钥匙形状的微凝胶将用于驱动自组装过程。 此外，将通过控制聚集参数（如搅拌力或几何形状）来开发生成分层自组装生物材料的方法。 最后，将优化所提出的自组装过程的各种参数，并将研究载细胞水凝胶的生物学性质作为凝胶尺寸、材料性质和大孔隙率的函数。组装过程适用于广泛的其他亲水性材料，并将解决材料科学中的一个基本问题，即缺乏自组装介观材料的过程。 所提出的方法是可扩展的，可以用来使材料与预定的空间organization.BroADER影响：拟议的研究将有更广泛的影响，在当地，国家和国际教育的水平，以及公众对生物学和材料科学的接口意识。 在地方一级，这项建议旨在为学生提供学习跨学科科学、进行研究和学习科学方法的专门知识。 PI通过UROP计划（本科生研究机会计划）监督麻省理工学院的本科生研究人员，并且是哈佛-麻省理工学院健康科学与技术部研究生的顾问。 PI将与UROP项目合作，招募本科生与项目团队的其他成员一起工作。 而且，PI会从麻省理工学院招生？麻省理工学院的MSRP研究项目，每年夏天都会从其他大学带来代表性不足的少数民族和妇女进行研究。 PI还将开发研究生课程，并与当地高中安排实地考察，教育学生有关生物材料研究。 在国家一级，PI将制定计划，对公众和其他机构的学生进行生物材料教育。 此外，PI将继续开展国际教育工作，并通过一些网络发起的努力开发可供公众和世界各地使用的材料。

ID: MPS/DMR/BMAT(7623) 0847287 PI: Khademhosseini, Ali ORG: Brigham&Womens HospitalTitle: CAREER: Mesoscale Self-assembly of Hydrophilic MaterialsThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).INTELLECTUAL MERIT: The ability to generate biocompatible materials with spatially organized chemical, biological and mechanical properties is of benefit for a wide range of applications. A powerful method for fabricating such materials is proposed through self-assembly of prefabricated shape-controlled microgels. In this proposal, a scalable approach to direct the mesoscale self-assembly of hydrophilic materials will be developed by using thermodynamic principles of multiphase systems and microengineering technologies. To achieve this goal, a two step bottom-up approach will be used in which microgels are initially assembled and subsequently stabilized by a crosslinking reaction. Surface tension forces at the water and oil interface along with lock-and-key shaped microgels will be used to drive the self-assembly process. In addition, approaches to generate hierarchical self-assembled biomaterials will be developed by controlling aggregation parameters such as agitation forces or geometry. Finally, the various parameters for the proposed self-assembling processes will be optimized and the biological properties of cell-laden hydrogels will be studied as a function of gel size, materials properties and macroporosity. The assembly process is applicable to a wide range of other hydrophilic materials and will address a fundamental problem in materials science regarding the lack of processes to self-assemble mesoscale materials. The proposed approach is scalable and can be used to make materials with predetermined spatial organization.BROADER IMPACTS: The proposed research will have broader impacts at the level of local, national and international education as well as public awareness about the interface of biology and materials sciences. At the local level this proposal aims to provide the students with expertise in learning about interdisciplinary science, performing research and learning the scientific method. The PI supervises undergraduate researchers at MIT through the UROP program (undergraduate research opportunity program) and is an advisor to graduate students of the Harvard-MIT Division of Health Sciences and Technology. The PI will work with the UROP program on recruiting undergraduate students to work with the other members of the team on the project. Furthermore, the PI will recruit students from MIT?s MSRP research program, which every summer brings underrepresented minorities and women to MIT from other universities for research. The PI will also develop graduate courses and arrange field trips with local high schools in educating students about biomaterials research. At the national level, the PI will develop programs for educating the public and students at other institutions about biomaterials. In addition, the PI will pursue international educational efforts and develop materials that will be available to the public and around the world through a number of web initiated efforts.