Studies on the regulation of the pro-apoptotic protein Bim in mammalian development and cancer.

该项目旨在了解一种基因的调控，这种基因是一种肿瘤抑制因子，在许多不同形式的癌症中经常发生突变或下调。更好地了解这种基因如何工作，最终可能会导致更好的治疗方法来治疗这些癌症。这在澳大利亚的情况下是相关的，因为我们的人口老龄化和肥胖流行病（肥胖，胰岛素抵抗和各种形式的癌症之间的联系已经确立）正在导致新癌症病例的快速增加，从而推动对更好治疗的需求迅速增加。这与土著人的健康特别相关，因为从传统生活方式向城市生活方式过渡后，肥胖症正在上升。

This project is aimed at understanding the regulation of a gene, which is a tumour suppressor and is often mutated or down regulated in many different forms of cancers. A better understanding of how this gene works may eventually lead to better therapeutics to treat these cancers. This is relevant in the Australian context given that our aging population and obesity epidemics (the link between obesity, insulin resistance and various forms of cancers is well established) are leading to a rapid increase in new cancer cases, thus driving a rapid increase in demand for better treatments. This is particularly relevant in Indigenous health where obesity is on the rise following the transition from a traditional to an urban lifestyle.