SBIR Phase I: High sensitivity nanoplasmonic biosensors

这个SBIR一期研究项目将展示一种光流芯片级生物传感器系统，用于无标签、高通量、实时监测和检测小体积、低成本的多种生化反应的动态。许多应用要求开发新的生物传感器，提供高灵敏度和分辨率，以检测单个或少量分子，并通过大量并行测试通道实现高通量，以增加测试变化谱并减少误报。该方法利用由优化的金属-介电复合纳米结构制成的二维纳米孔阵列穿孔的金属薄膜中新型极化敏感激发和表面等离子体激振共振检测的研究结果，显著提高了生物传感器的灵敏度和分辨率。这种生物传感器系统将具有直接的技术和商业影响，因为它以低成本提供独特的性能特征（例如，无标签，高通量筛选，高灵敏度）。拟议的生物传感器系统还将影响军事、国土安全、农业和环境监测应用中生化剂的检测。该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。

This SBIR Phase I research project will demonstrate an opto-fluidic chip-scale bio-sensor system for label-free, high-throughput, real-time monitoring and detection of dynamics of multitude of biochemical reactions in small volumes and at low cost. Numerous applications urge development of new biological sensors that provide high-sensitivity and resolution to enable detection of single or small number of molecules and high-throughput enabled by large numbers of parallel testing channels to increase test variation spectrum and reduce false alarms. The proposed approach significantly enhances the biosensor sensitivity and resolution by utilizing the results of research on novel polarization sensitive excitation and detection of surface plasmon polariton resonance in metal films perforated by 2D nanohole arrays made of optimized metal-dielectric composite nanostructure. This bio-sensor system will have direct technological and commercial impact because it provides unique performance characteristics (e. g., label-free, high throughput screening, high-sensitivity) at low cost. The proposed bio-sensor system will also impact detection of bio-chemical agents in military, homeland security, agriculture, and environment monitoring applications.This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).