SBIR Phase I: Food Antioxidants (AOs) With or Without Estrogenic Activity (EA)

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)资助的。这个小型企业创新研究第一阶段项目将证实，确定食品抗氧化剂(AO)以制造没有可检测到的雌激素活性(EA)或抗EA(EA-Free)的配方或具有明确的EA水平(EA-特定的AO配方)是可行的。这个项目是创新的，因为以前没有检查过食品AO的EA水平，特别是在常用的杀菌或微波压力之后。由于其独家专利和将不含EA的产品推向市场的经验，CertiChem是唯一有资格开发和商业化不含EA/指定EA的AO配方的公司。这项研究的更广泛影响是，CertiChem的数据显示，目前大多数食品AO含有未知浓度的EA。认证化学公司建议开发不含EA或具有明确EA水平的AO配方。食品中含有乙酸乙酯浓度的化学物质(毫米到微米)通常对哺乳动物，包括人类有不利影响。胎儿或幼年哺乳动物对极低剂量(从NM到PM浓度)的EA的化学物质的影响特别敏感。相反，成年人的一些情况(例如，更年期、某些癌症或前列腺异常)可能会通过含有特定水平的EA的化学物质而得到改善。认证化学公司正在通过积极与非政府组织和立法者合作，教育公众与含有EA的化学品相关的健康风险或好处，从而提高消费者的意识。已经观察到消费者对不含EA的产品或EA指定的产品的巨大需求。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Small Business Innovation Research Phase I project will confirm that it is feasible to identify food antioxidants (AOs) to make formulations that have no detectable estrogenic activity (EA) or anti-EA (EA-Free) or have well-specified levels of EA (EA-Specified AO formulations). This project is innovative because food AOs have not previously been examined for levels of EA, especially after common-use-stresses of sterilizing or microwaving. CertiChem is uniquely qualified to develop and commercialize EA-free/EA-specified AO formulations because of its exclusive patents and experience in bringing EA-Free products to market.The broader impacts of this research are that CertiChem's data show that most current food AOs have EA in unknown concentrations. CertiChem proposes to develop AO formulations that are EA-Free or have well-specified levels of EA. Chemicals having EA at concentrations used in foodstuffs (mM to uM) often have adverse effects on mammals, including humans. Fetal or juvenile mammals are especially sensitive to effects of chemicals having EA at very low dosages (nM to pM concentrations). Conversely, some conditions in adult humans (e.g., menopause, some cancers or abnormalities of the prostate) are probably ameliorated by chemicals having well-specified levels of EA. CertiChem is raising consumer awareness by actively working with NGOs and legislators to educate the public on health risks or benefits associated with chemicals that have EA. Significant consumer demand for EA-Free products or EA-Specified products is already observed.