STTR Phase I: Multifunctional Magnetic Core-Shell Nanoparticles

这个小型企业技术转移第一阶段项目是为了制造多功能磁性核壳纳米颗粒，以证明合成由磁性纳米颗粒核心和金壳和/或银壳组成的核壳纳米颗粒的可行性。这种纳米复合材料将被设计成从金壳或银壳表现出可控的表面反应性(和生物兼容性)，以及从磁芯中表现出磁分离能力。在多功能纳米材料的开发中，建议的方法的广泛影响有三个方面。首先，金属的纳米工程能够大幅增加表面积和其他性质的变化，以实现更好的生物探测和抗菌活性。其次，纳米级的金/银外壳降低了生产成本，降低了毒性，并具有更好的抗菌性能。第三，磁芯的引入使生物探针和抗菌剂能够有效和受控地分离、输送和靶向。这类产品不仅针对与磁珠相同的磁选商业化市场，而且还针对生物技术的许多新领域。该奖项由2009年美国复苏和再投资法案(公法111-5)资助。

This Small Business Technology Transfer Phase I project is for the manufacture of multifunctional magnetic core-shell nanoparticles to demonstrate the feasibility of synthesizing core-shell nanoparticles consisting of magnetic nanoparticle cores and gold and/or silver shells. Such nanocomposite materials will be engineered to display controllable surface reactivity (and biocompatibility) from the gold or silver shells, and magnetic separation capability from the magnetic cores. The broad impact of the proposed approach is three-fold in the development of multifunctional nanomaterials. First, the nanoengineering of the metals enables a drastic increase of the surface area and other changes in properties for better bio-probing and antibacterial activity. Secondly, the nanoscale gold/silver shells lead to reduction of the production costs, toxicity and better antimicrobial characteristics. Thirdly, the introduction of magnetic cores enables the capabilities of effective and controlled separation, delivery and targeting of the bio-probes and antibacterial agents. Such products target not only the same commercialization market as magnetic beads in magnetic separation but also many new areas of biotechnologies.This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).