SBIR Phase I: Novel Advanced Nematicides with Improved Efficacy and Safety

该SBIR一期项目将使用专有的化学设计和筛选方法开发新型杀线虫剂。该项目将首先设计、排序并合成一组全新的分子。然后，该项目将评估化合物在寄生线虫和植物的多种生物分析中的活性。有前景的支架将优先在II期进行进一步开发，包括评估毒性、制造成本和额外的合成机会。该项目的更广泛/商业影响将是保护作物免受线虫的侵害，这将为种植者和环境带来重大利益。Divergence的潜在价值非常大，目前杀线虫剂市场的10亿美元低于可能产生的实际价值。由此产生的有效的杀线虫剂比目前的产品具有更高的安全性，将对种植者、消费者和环境产生直接的好处。

This SBIR Phase I project will develop novel nematicides using proprietary chemical design and screening methods. The project will first design, prioritize, and synthesize a set of entirely novel molecules. The project will then evaluate compounds for activity in multiple biological assays with parasitic nematodes and plants. Promising scaffolds will be prioritized for further development in Phase II including assessment of toxicity, manufacturing cost, and additional synthetic opportunities.The broader/commercial impact of the project will be to protect crops against nematodes which result in significant benefit to growers and the environment. The potential value to Divergence is very large, with the current nematicide market of $1 billion under representing the actual value that could be generated. REsulting effective nematicides with superior safety to current prodicts will be of immediate benefit to growers, consumers, and the environment.