Rh-catalyzed Asymmetric Hydroformylation Reaction

在化学系化学合成计划的支持下，张旭木教授和罗格斯大学新不伦瑞克分校的同事们开展了高活性、区域选择性和不对称氢甲酰化反应的研究。将设计和合成用于Rh催化的不对称氢甲酰化反应的手性配体。将对控制反应选择性的因素进行调查。所合成的手性配体和开发的不对称反应将在一些具有挑战性的手性药物和精细化工产品的不对称合成中展示其合成用途。氢甲酰化反应是化学工业中重要的基础过程。高效的不对称氢甲酰化反应的发展将对精细化学品的工业生产产生重要影响。此外，利用这些反应来提高手性生物活性化合物不对称合成的效率，以及对学生进行催化和合成有机化学方面的研究培训，将有利于制药行业。

With the support from the Chemical Synthesis Program in the Division of Chemistry, Prof. Xumu Zhang and coworkers at Rutgers University New Brunswick conduct research to develop highly reactive, regioselective, and enantioselective asymmetric hydroformylation reactions. Chiral ligands for use in Rh-catalyzed asymmetric hydroformylation reactions will be designed and synthesized. Factors that control the selectivities of the reactions will be investigated. The synthetic utility of the chiral ligands synthesized and the asymmetric reactions developed will be demonstrated in a few challenging asymmetric syntheses of chiral pharmaceutical and fine chemical products.Hydroformylation reaction is an important fundamental process in chemical industry. The development of efficient asymmetric hydroformylation reactions would have an important impact on the industrial production of fine chemicals. Furthermore, the use of these reactions to improve efficiencies of asymmetric syntheses of chiral bioactive compounds and the research training of students in catalysis and synthetic organic chemistry would benefit the pharmaceutical industry.