SBIR Phase I: Commercialization and Scale Up of Ultra Low Fouling and Functionalizable Surface Coatings Based on Zwitterionic Polycarboxybetaine

该小型企业创新研究（SBIR）第一阶段项目旨在批量生产超低污染和可功能化的聚羧基甜菜碱（pCB）表面涂层。 该方法是开发一种新的路线，具有成本效益和大规模生产的两性离子羧基甜菜碱（CB）单体。 一种新的方法来制备高品质的pCB表面涂层也将investigated.The更广泛的/商业的影响，这个项目将是潜在的两性离子材料/表面涂层技术，在医疗器械和生物传感器，药物输送和消费品的应用。 两性离子pCB不仅对非特异性蛋白质吸附具有高抗性，而且具有丰富的官能团，可通过常规化学方法方便有效地固定生物分子。 这使得pCB成为从诊断到药物输送的许多应用的理想选择。 然而，制造pCB涂层的主要挑战之一是CB单体不可商购。 该项目将通过开发CB单体和pCB涂层的大规模生产工艺来应对这一挑战。

This Small Business Innovation Research (SBIR) Phase I project aims to enable the batch production of ultra-low fouling and functionalizable polycarboxybetaine (pCB) surface coatings. The approach is to develop a new route for the cost-effective and large-scale production of the zwitterionic carboxybetaine (CB) monomers. A novel approach to prepare high quality pCB surface coatings will also be investigated.The broader/commercial impact of this project will be the potential to provide zwitterionic materials/surface coatings technology for applications in medical devices and biosensors, drug delivery and consumer products. Zwitterionic pCB is not only highly resistant to nonspecific protein adsorption, but also has abundant functional groups for the convenient and effective immobilization of biomolecules via conventional chemistry. This makes pCB an ideal choice for many applications from diagnostics to drug delivery. However, one of the major challenges in manufacturing of pCB coatings is that CB monomers are not commercially available. This project will address this challenge by developing a process for large-scale production of CB monomers and pCB coatings.