SBIR Phase I: System for creation and use of realistic cardiac electromechanical simulation models

这个小企业创新研究（SBIR）第一阶段项目将探索一个用户友好的跨平台计算系统的开发和商业可行性，用于多尺度组织和器官心脏电生理和电力学建模。具体技术目标包括：1)评估装配自动化管道的技术可行性；2)评估开发集成心脏机电模型组装、仿真和分析的跨平台图形用户界面（GUI）的技术可行性；3)测试和完善原型系统以满足客户需求，并利用用户输入来评估系统的商业可行性。该系统将有助于发现和开发心脏病诊断和治疗的新方法，并允许从蛋白质到整个器官对心律紊乱和机电功能障碍的机制进行虚拟探索。该系统将包括直接输入心脏成像数据的能力。用户将能够定制系统的单个组件的行为，以代表特定的心脏病理，目标和干预措施。模拟将易于管理，并且一个强大的跨平台用户友好界面将允许毫不费力地可视化结果。该项目的广泛影响/商业潜力源于他提出的系统代表了心脏机电仿真方式的巨大范式转变。它不仅将在一个易于使用的系统中集成心脏电和机械功能，使用迄今为止开发的最复杂的心脏模拟工具，而且还打算使模拟能够进入社会的一个非常广泛的方面。目前，心脏建模仅在少数学术实验室中用于探索心脏病诊断和治疗的新方法。然而，心脏设备制造、生物技术和制药行业对心脏组织和器官建模有很大的兴趣。对于设备公司来说，它提供了一个开发和测试原型设备和治疗方式的机会。对于制药公司来说，它提供了一个无与伦比的机会来快速筛选药物的抗心律失常作用。它还为学术研究人员提供了好处，因为先进的先进模拟工具将开辟新的研究视野，特别是个性化医疗的转化研究项目。最后，该系统有望成为一个有效的教学工具，并成为生物医学和临床课程的一部分。

This Small Business Innovation Research (SBIR) Phase I project will explore the development and commercial feasibility of a user-friendly cross-platform computing system for multi-scale tissue and organ cardiac electrophysiology and electromechanics modeling. Specific technical objectives include: 1) Assessing the technical feasibility of assembling an automated pipeline; 2) Assessing the technical feasibility of developing a cross-platform graphic user interface (GUI) that integrates cardiac electromechanical model assembly, simulation, and analysis; and 3) Testing and refining the prototype system to meet customer needs and utilizing user input to assess the commercial feasibility of the system. The proposed system will enable the discovery and development of new approaches to the diagnosis and treatment of cardiac disease and allow virtual exploration of mechanisms of cardiac rhythm disorder and electromechanical dysfunction, from the protein to the entire organ. The system will include capabilities for direct input of cardiac imaging data. Users will be able to tailor the behavior of individual components of the system to represent specific cardiac pathologies, targets, and interventions. Simulations will be managed with ease,and a robust cross-platform user-friendly interface will allow effortless visualization of results.The broader impact/commercial potential of this project stems from the fact that he proposed system represents an enormous paradigm shift in the way cardiac electromechanical simulation is done. It will not only integrate, in one easy-to-use system, cardiac electrical and mechanical function using the most sophisticated cardiac simulation tools ever developed, but intends to make simulation accessible to a very broad aspect of society. Currently, cardiac modeling is used in the exploration of new approaches to the diagnosis and treatment of cardiac disease only in a few academic laboratories. However, cardiac device manufacturing, biotech, and pharmaceutical industries have a significant interest in cardiac tissue and organ modeling. For device companies, it presents an opportunity to develop and test prototype devices and treatment modalities. For pharmaceutical companies, it offers an unrivaled opportunity to quickly screen drugs for proarrhythmic effects. It also provides benefits to academic researchers since sophisticated state-of-the-art simulation tools will open new research horizons, particularly translational research projects in personalized medicine. Finally, the proposed system is expected to become an effective teaching tool, and part of biomedical and clinical curricula.