RUI: Fundamental Studies on the Separation Mechanisms of Porous Polymer Monoliths

三一大学的Michelle M. Bushey教授在化学系化学测量和成像（CMI）项目的支持下，在HPLC和毛细管电色谱（CEC）中对分析物和流动相与有机聚合物整体固定相的相互作用进行了基础研究。目的是对有机聚合物整体固定相的分离机制有一个基本的了解。对于不同的分析物，不同的流动相和不同的丙烯酸酯和甲基丙烯酸酯单体聚合物，热力学性质和扩散系数将作为保留因子的函数进行测量。对这些相互作用的透彻理解将影响实际色谱分离中高效固定相的开发。用常规固定相进行色谱分离模拟，极大地提高了分离性能。缺乏对聚合物整体固定相色谱的平行基本理解阻碍了这些独特分析分离介质的发展和广泛接受。本科学生将在种族多元化的本科院校接受分析分离科学与技术方面的培训。

Professor Michelle M. Bushey of Trinity University is supported by the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry to conduct a fundamental study of the interactions of analytes and the mobile phase with organic polymer monolith stationary phases in HPLC and capillary electrochromatography (CEC). The objective is to derive a basic understanding of the separation mechanisms with organic polymer monolith stationary phases. Thermodynamic properties and diffusion coefficients will be measured as a function of retention factor for different analytes, different mobile phases and different acrylate and methacrylate monolithic polymers. A thorough understanding of these interactions will impact the development of efficient stationary phases for practical chromatographic separations. Modeling of chromatographic separations with conventional stationary phases has resulted in great improvement in separation performance. The lack of a parallel basic understanding of chromatography with polymer monolith stationary phases hampered the development and limited the broad acceptance of these unique analytical separation media. Undergraduate students will be trained in analytical separation science and technology in an ethnically diverse undergraduate institution.