CAREER: Multidimensional Selective Excitation in NMR

化学测量和成像计划的职业奖支持迈阿密大学（UM）的Jamie Walls教授开发利用核磁共振（NMR）的新技术，这是磁共振成像（MRI）背后的基础光谱学。 在常规NMR中，需要多次测量以获得完整的化学信息，通常需要非常长的实验采集时间。 沃尔斯博士正在开发一种替代的“多维”方法，在一个实验中产生信号。 该方法基于自旋跃迁之间的相关性，而不是单个自旋跃迁频率，并且可以帮助加速生物分子和其他系统的结构和动态NMR研究，并减少MRI成像时间。在培养本科生、研究生和博士后研究人员的过程中，Walls博士正在开发一个新的成像和光谱实验室，该实验室使用NMR来说明数值模拟在实验科学中的重要性。 Walls博士与他的本科生和研究生一起工作，还开发了每周科学广播节目La Semana en Ciencia（科学周），该节目将在UM传播学院的广播工作室以英语和西班牙语制作。 该计划将突出新科学发现的兴奋和重要性，旨在提高科学素养，并激励学生考虑从事科学职业。 La Semana en Ciudad将使西班牙裔学生更容易获得尖端科学，他们传统上在科学学科中代表性不足。

This CAREER award from the Chemical Measurement and Imaging Program supports work by Professor Jamie Walls at the University of Miami (UM) to develop a new class of techniques utilizing nuclear magnetic resonance (NMR), the fundamental spectroscopy behind magnetic resonance imaging (MRI). In conventional NMR, multiple measurements are needed in order to acquire full chemical information, often requiring very long experimental acquisition times. Dr. Walls is developing an alternative "multidimensional" approach that generates signal in a single experiment. The method is based upon correlations between spin transitions rather than individual spin transition frequencies, and may help speed up structural and dynamical NMR studies of biomolecular and other systems, and reduce MRI imaging times. It may also prove applicable to other spectroscopies and disciplines.In the course of training undergraduate, graduate and postdoctoral researchers, Dr. Walls is developing a new imaging and spectroscopy lab that uses NMR to illustrate the importance of numerical simulations in experimental science. Working with his undergraduate and graduate students, Dr. Walls is also developing a weekly science radio program, La Semana en Ciencia (The Week in Science), that will be produced in both English and Spanish at the UM School of Communication's radio studio. The program will highlight the excitement and importance of new scientific discoveries, with aims of enhancing science literacy and inspiring students to consider careers in science. La Semana en Ciencia will make cutting edge science more accessible to Hispanic students, who are traditionally underrepresented in scientific disciplines.