Acqusition of Partcle Sizer

PI: Marek Romanowski提案No. 1061200粒径的获取摘要本提案的主要目标是获得适合于测定纳米尺度上制备的各种颗粒的粒径分布的粒径仪，用于医学诊断和治疗的实验应用。该实验室的主要研究工作是开发用于医学诊断和干预的纳米级工程结构。这种尺寸范围不仅与分子靶向和细胞传递兼容，而且还允许对材料进行前所未有的光学和电子特性控制，专门为生物医学应用量身定制。本实验室产生的例子包括可生物降解等离子体共振纳米壳和光谱控制含量释放。由该粒度仪产生的数据将有助于该研究者开发的多功能纳米结构的光学和生物学特性的操作过程。此外，该提案还解决了该地区几位需要在纳米尺度上表征材料的研究人员的需求。亚利桑那大学生物医学工程系的教员所从事的与分子成像和靶向治疗、胶体化学和蛋白质构象有关的研究项目中，这种特性变得尤为重要。因此，本提案的目的之一是为在该地点从事相关研究方向的研究人员提供使用这种仪器能力的途径。最后，本提案的一个组成部分是为对纳米尺度工程材料感兴趣的学生提供研究和教育机会，并加强光子学，材料科学和纳米医学领域的教育课程。

PI: Marek Romanowski Proposal No. 1061200Acquisition of Particle SizerAbstractThe main goal of this proposal is to acquire a particle sizer appropriate for determination of size distributions of various particles prepared on the nanometer scale for experimental applications in medical diagnostics and therapy. The main thrust of the research work in this laboratory has been to develop engineered structures in the nanometer size range for medical diagnosis and intervention. Not only is this size range compatible with molecular targeting and cellular delivery, but it also allows for the manipulation of materials with unprecedented control of their optical and electronic properties, specifically tailored for biomedical applications. Examples generated in this laboratory include biodegradable plasmon resonant nanoshells and spectrally controlled content release. Data generated by this particle sizer will help the process of manipulation of optical and biological properties of multifunctional nanostructures developed by this investigator. In addition, this proposal addresses the need of several researchers at this location who require characterization of materials on the nanometer scale. Such characterizations have become especially important in research programs concerned with molecular imaging and targeted therapy, colloidal chemistry, and conformation of proteins, pursued by the faculty associated with the Department of Biomedical Engineering at the University of Arizona. Therefore, one of the aims of this proposal is to provide access to this instrumental capability to researchers pursuing related research directions at this location. Finally, an integral part of this proposal is to provide research and educational opportunities to students with interest in engineering materials on the nanometer scale, and to enhance educational curriculum in the areas of photonics, material science, and nanomedicine.