Studies of New Ionization Approaches in Mass Spectrometry for Imaging

在化学测量和成像计划的支持下，科学大学的查尔斯·N·麦克尤恩教授寻求加深对某些新开发的质谱学(MS)电离方法的理解，目的是提高重复性和灵敏度。这些电离方法(与韦恩州立大学的Sarah Trimpin教授合作发现)具有基质辅助激光解吸/电离(MALDI)和电喷雾电离(ESI)两种属性。它们各自产生多电荷离子，类似于ESI，允许分析高质量化合物并增强离子迁移率技术的实用性。提高这些新电离方法的灵敏度和重复性，可能使大气条件下的高空间分辨率成像成为可能。需要高通量分析的领域(如消费者保护、反恐、环境监测、临床应用和生物材料分析)将受到这些发展的影响。研究生和本科生所接受的广泛培训将增强他们未来的科学潜力。

With support from the Chemical Measurement and Imaging Program, Professor Charles N. McEwen of the University of the Sciences seeks improved understanding of certain newly developed mass spectrometric (MS) ionization methods, with aims of improving reproducibility and sensitivity. These ionization methods (discovered in collaboration with Professor Sarah Trimpin of Wayne State University) have attributes of both matrix assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). They each produce multiply charged ions, similar to ESI, allowing analysis of high mass compounds and enhancing utility of ion mobility techniques. Increasing the sensitivity and reproducibility of these new ionization methods may make possible high spatial resolution imaging under atmospheric conditions. Areas requiring high throughput analyses (such as consumer protection, counter-terrorism, environmental monitoring, clinical applications, and biological materials analysis) will be impacted by these developments. The broad training gained by the graduate and undergraduate students involved will enhance their future scientific potential.