International Collaboration in Chemistry: Catalytic Atom-Economical Aromatic Substitution via Radicals

化学结构、动力学和机制项目支持里海大学R. A. Flowers教授的“国际化学合作”项目。外国研究者是来自德国的A. Gansäuer教授，他对合作项目的贡献将得到德国科学基金会（DFG）的支持。研究人员将开发金属催化剂，通过采用碳中心自由基的均溶取代来实现芳香化合物的功能化。C-C键的形成具有重要的基础意义，新的进展将有助于有机化合物特别是芳香族化合物的可持续合成。德国PI提供在有机合成中使用自由基催化的专业知识，美国PI提供有机反应的机理研究。Flowers教授和Gansäuer教授将详细了解催化二茂钛基自由基反应，为芳烃功能化提供有效和选择性的方法。芳烃是苯乙烯等许多化工产品的核心原料。这项工作的目标之一是提供光学富集的芳基-2-丙醇，这是合成非甾体抗炎药（NSAIDS）的基石。国际团队将包括本科生和研究生，他们将接受标准有机化学实验室通常不涉及的技术的多学科培训。

The Chemical Structure, Dynamics and Mechanisms Program supports Professor R. A. Flowers from Lehigh University on an "International Collaboration in Chemistry" project. The foreign investigator is Professor A. Gansäuer from Germany, whose contribution to the collaborative project will be supported by the German Science Foundation (DFG). The researchers will develop metal catalysts for the functionalization of aromatic compounds via homolytic substitutions employing carbon centered radicals. The formation of C-C bonds is of fundamental importance and new developments will contribute to the sustainable synthesis of organic compounds, in particular aromatic compounds. The German PI provides expertise in the use of radical catalysis in organic synthesis, the US PI in mechanistic studies of organic reactions. Professors Flowers and Gansäuer will pursue a detailed understanding of catalytic titanocene based radical reactions to provide efficient and selective approaches for arene functionalization. Arenes are at the center of many chemical commodity products such as styrene. One of the goals of this work is to furnish optically enriched aryl-2-propanols, which form the building blocks for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDS). The international team will include undergraduate and graduate students who will receive multidisciplinary training in techniques not typically covered in standard organic chemistry laboratories.