GRK 1427: Food Constituents as Triggers of Nuclear Receptor-mediated Intestinal Signalling

公众对食品安全的担忧要求开发一个可靠的数据库，以了解食品成分对人类健康的影响。研究培训小组旨在将对这一需求的贡献与生物医学方面的高影响力基础研究联系起来。目前关于细胞周期、增殖和细胞死亡的知识表明，众所周知的膳食毒物以及被认为对人类健康有益的膳食抗氧化剂的作用机制比过去预期的要复杂得多。研究重点从单分子的损伤和保护转向对复杂的细胞调控网络的更复杂的干扰。

Public concern about food safety calls for the development of a reliable data base for the impact of food constituents on human health. The Research Training Group aims at linking a contribution to this demand with high impact basic research in biomedicine. Current knowledge about cell cycle, proliferation and cell death suggests that the mechanisms of action of well-known dietary toxicants but also of dietary antioxidants assumed to be beneficial to human health are much more complicated than expected in the past. The research focus shifts from damage and protection of single molecules to more sophisticated interference with the complex network of cellular regulation.