Workshop: Phenomes - Beyond Genomes; April 1-2, 2011; St. Louis, MO

智力价值：为期两天的研讨会将于2011年4月1日和2日在密苏里州圣路易斯市举行，来自不同领域的20-25名受邀学者将讨论如何在基因组资源开发(基因组测序和注释、遗传和物理图谱、基因表达数据集、突变体库、蛋白质组和各种其他“组学”)方面的投资能够被利用并在新兴的“表型研究”领域得到进一步发展。四位主旨演讲者将就表现学的广泛主题发表演讲，为会议定下基调，并推动讨论。所有与会者将有充分的机会在每次主旨演讲后立即举行的集思广益会议上就关键问题和问题进行讨论，通过专门针对重大挑战的分组讨论，并通过参与编写白皮书作为研讨会的记录和出版成果。讲习班的基本目的是鼓励进行实质性和及时的跨学科对话，以便可以制定新的联邦资助优先事项。研讨会将包括使用“自上而下”(表型到基因)和“自下而上”(基因到表型)方法的研究人员的参与。这些科学家代表的研究领域从相对简单的单一物种研究到复杂的多有机体系统。参与者被邀请来自使用一系列系统和生物的不同领域，包括植物育种、微生物学、元基因组学、生物信息学和系统生物学。更广泛的影响：研讨会的白皮书将概述在以易于处理和富有成效的方式将表型信息与基因组信息相结合方面面临的重大挑战。白皮书将阐明加强整合和协调可能带来的好处；确定目前在知识、基础设施和学科互动方面的差距；并建议研究和资金方面的方向。澄清和列举短期和长期目标将有利于从计算机科学到农业等一系列兴趣和专业知识的研究人员和政府机构。预计白皮书将促成跨学科的对话和合作，以将表型学确立为一门充满活力的学科，涵盖支撑表型变异的全方位的基因与环境相互作用。此外，研讨会将包括来自不同职业阶段、机构类型、地理位置、性别和种族背景的学者。

Intellectual Merit: A two-day workshop to be held on April 1 and 2, 2011 in St. Louis, Missouri will bring 20-25 invited scholars from diverse fields to address how investments in genome resource development (genome sequencing and annotation, genetic and physical mapping, gene expression datasets, mutant collections, proteomic and various other "omics") can be leveraged and further developed in the emerging field of "Phenomics", the study of phenotypes. Four keynote speakers will deliver presentations on the broad topic of Phenomics to set the tone of the meeting and catalyze discussion. All participants will have ample opportunity for conversation on key questions and issues in brainstorming sessions immediately following each keynote talk, through breakout groups specifically oriented to the identification of grand challenges, and through participation in the production of a White Paper as a recorded, published outcome of the workshop. The fundamental purpose of the workshop is to encourage substantive and timely cross-disciplinary dialog such that new formulations of priorities for Federal funding may emerge. The workshop will include participation from researchers using "top-down" (phenotype to genotype) and "bottom-up" (genotype to phenotype) approaches. These scientists represent areas of research ranging from relatively simple single species studies through complex multi-organism systems. Participants were invited from a diverse set of fields using a range of systems and organisms, including plant breeding, microbiololgy, metagenomics, bioinformatics and systems biology. Broader Impacts: The White Paper from the workshop will outline grand challenges that lie ahead in integrating phenotypic with genomic information in a tractable and productive manner. The Paper will articulate what benefits could arise from increased integration and coordination; identify current gaps in knowledge, infrastructure, and disciplinary interactions; and recommend directions in research and funding. Clarification and enumeration of short- and long-term goals will be of benefit to researchers and government agencies spanning a range of interests and expertise from computer science to agriculture. It is expected that the White Paper will seed cross-disciplinary dialog and collaborations to establish Phenomics as a vibrant discipline encompassing the full range of genotype by environment interactions that underpin phenotypic variation. Additionally, the workshop will include scholars from diverse career stages, institutional types, geographical locations, gender and ethnic backgrounds.