EAGER: Testing genotype-hormone associations in circumpolar ancestral and descendant populations

这是一个EAGER的建议，旨在为随后对北极土著妇女生殖激素水平的环境，行为和遗传决定因素的研究奠定基础。有强有力的科学证据表明，本项目中研究的类固醇激素浓度会影响怀孕能力，并且是几种疾病的重要风险因素（例如，乳腺癌和其他癌症、心血管疾病），但对北极地区绝经前妇女体内这些激素的变化知之甚少。EAGER项目是一个实验性项目，旨在评估特定基因座的遗传变异是否有助于环极祖先（中亚）和后代（南美土著）人群的激素变异。研究人员希望该项目能够提供1）经过验证的女性激素浓度的现场，实验室和统计方法，以及2）有价值的和新颖的数据，用于未来对极地人群的研究。此外，PI将积极参与阿拉斯加、加拿大和格陵兰的社区外联活动，以便向土著社区通报EAGER研究的结果，并在更广泛的环极地研究中征求社区的兴趣和合作。该项目在定义与类固醇激素相关的特定基因组的科学潜力和创建社区合作项目的更广泛影响方面都具有潜在的变革性，该项目有可能更深入地了解影响这些社区的致命疾病。

This is an EAGER proposal to establish the foundation for subsequent research on the environmental, behavioral, and genetic determinants of reproductive hormone levels in indigenous arctic women. There is strong scientific evidence that concentrations of the steroid hormones investigated in this project influence the capacity to conceive and are significant risk factors for several diseases (e.g., breast and other cancers, cardiovascular disease), yet very little is known about the variation of these hormones among pre-menopausal women in the arctic. This EAGER project is an experimental project designed to evaluate whether genetic variation at specific loci contribute to hormonal variation in circumpolar ancestral (Central Asian) and descendant (indigenous South American) populations. The researchers expect this project to provide 1) validated field, laboratory and statistical approaches to hormone concentrations in women, and 2) valuable and novel data for the anticipated future study of circumpolar populations. In addition, the PI will be actively involved in community outreach in Alaska, Canada, and Greenland in order to inform indigenous communities of the findings from the EAGER research and solicit community interest and collaboration in a broader circumpolar study. This project is potentially transformative in both the scientific potential to define a specific genome related to steroid hormones and in the broader impacts of creating a community collaborative project that has the potential to gain deeper insight into fatal diseases affecting these communities.