NMR Investigations of the Self Organization and Dynamics of Amyloid Protein Fibrils (A06)

该项目的目标是了解蛋白质原纤维形成的基本基础。我们用核磁共振方法研究了蛋白质自组织过程的不同阶段以及蛋白质的结构和动力学。为此，我们通过在淀粉样蛋白β(Aβ40)的这些位置引入特定的物理场或修改淀粉样蛋白结构的更大片段来系统地改变这些已知的分子接触。这些修改对结构形成过程起到内部约束作用。

The goal of the project is to understand the fundamental basis of protein fibril formation. We study the different stages of the self-organization process and the structure and dynamics of the protein by NMR methods. To this end, we systematically alter well-known molecular contacts of amyloid β (Aβ40) peptides by introducing specific physical fields into these positions or modifying larger segments of the amyloid structure. These modifications act as internal constraints on the structure forming process.